The long-term objectives are to study how potasslunn channels regulation contributes to neuronal signaling.
The specific aims are to understand how the dendritic voltage-gated potassium channels and G proteinactivated inwardly rectifying potassium (GIRK) channels are regulated in hippocampal neurons, and how these potassium channels contribute to neuronal signaling and synaptic plasticity. The research design involves examination of mutant mice with altered or deleted potassium channel regulatory proteins, for regulation of either the local synthesis of channels in the dendrite or the activity or kinetic properties of the channel on the cell membrane. Because the Kv1 voltage-gated potassium channels reside on both dendrites and axons, the mosaic analysis with double markers (MADM) approach will be employed to study the physiological role of dendritic Kv1 channels.
Mental disorders may involve an imbalance between excitation and inhibition. Whereas current studies focus primarily on synaptic function, little is known about the regulation of slow synaptic inhibition or plasticity of dendritic excitability that contributes to experience-induced changes of information processing. It is therefore important to study the physiological contribution of dendritic potassium channels.
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|Thayer, Desiree A; Yang, Shi-Bing; Jan, Yuh Nung et al. (2016) N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels. J Physiol 594:6701-6713|
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|Huang, Xi; Jan, Lily Yeh (2014) Targeting potassium channels in cancer. J Cell Biol 206:151-62|
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|Sun, Yaping; Dong, Zhiqiang; Jin, Taihao et al. (2013) Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife 2:e00508|
|Isacoff, Ehud Y; Jan, Lily Y; Minor Jr, Daniel L (2013) Conduits of life's spark: a perspective on ion channel research since the birth of neuron. Neuron 80:658-74|
|Thayer, Desiree A; Jan, Yuh Nung; Jan, Lily Yeh (2013) Increased neuronal activity fragments the Golgi complex. Proc Natl Acad Sci U S A 110:1482-7|
|Yang, Huanghe; Kim, Andrew; David, Tovo et al. (2012) TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell 151:111-22|
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