Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37NS014610-24
Application #
6751799
Study Section
Special Emphasis Panel (NSS)
Program Officer
Mitler, Merrill
Project Start
1983-02-01
Project End
2006-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
24
Fiscal Year
2003
Total Cost
$296,982
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Shan, Ling; Dauvilliers, Yves; Siegel, Jerome M (2015) Interactions of the histamine and hypocretin systems in CNS disorders. Nat Rev Neurol 11:401-13
Ramanathan, Lalini; Siegel, Jerome M (2014) Gender differences between hypocretin/orexin knockout and wild type mice: age, body weight, body composition, metabolic markers, leptin and insulin resistance. J Neurochem 131:615-24
John, Joshi; Kodama, Tohru; Siegel, Jerome M (2014) Caffeine promotes glutamate and histamine release in the posterior hypothalamus. Am J Physiol Regul Integr Comp Physiol 307:R704-10
Hsieh, Kung-Chiao; Nguyen, Darian; Siegel, Jerome M et al. (2013) New pathways and data on rapid eye movement sleep behaviour disorder in a rat model. Sleep Med 14:719-28
Blouin, Ashley M; Fried, Itzhak; Wilson, Charles L et al. (2013) Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction. Nat Commun 4:1547
John, Joshi; Thannickal, Thomas C; McGregor, Ronald et al. (2013) Greatly increased numbers of histamine cells in human narcolepsy with cataplexy. Ann Neurol 74:786-93
Scammell, T E; Matheson, J K; Honda, M et al. (2012) Coexistence of narcolepsy and Alzheimer's disease. Neurobiol Aging 33:1318-9
McGregor, Ronald; Wu, Ming-Fung; Barber, Grace et al. (2011) Highly specific role of hypocretin (orexin) neurons: differential activation as a function of diurnal phase, operant reinforcement versus operant avoidance and light level. J Neurosci 31:15455-67
Wu, Ming-Fung; Nienhuis, Robert; Maidment, Nigel et al. (2011) Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy. J Neurosci 31:6305-10
Wu, M-F; Nienhuis, R; Maidment, N et al. (2011) Cerebrospinal fluid hypocretin (orexin) levels are elevated by play but are not raised by exercise and its associated heart rate, blood pressure, respiration or body temperature changes. Arch Ital Biol 149:492-8

Showing the most recent 10 out of 82 publications