This is the competitive renewal for a grant that has led to several key discoveries in the field of oligodendrocyte cell identity. Based on our previous record of productivity, solid preliminary data and resources and the collaboration with leaders in the field of epigenetics, chromatin and system biology, we propose to continue to elucidate mechanisms of oligodendrocyte differentiation and myelin formation. The proposed experimental plan will impact not only the field of neurobiology, but also address important biological questions with implications for a broad range of disciplines and contribute to the development of novel therapeutic strategies.

Public Health Relevance

Epigenetic mechanisms serve as an interface between the environment and gene expression and they are responsible for the long-lasting changes in nuclear chromatin that define cell identity. We study these mechanisms in oligodendrocyte lineage cells. The goal is to define their potential role for repair of neonatal and adult neuropathologies as well as psychiatric disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37NS042925-17
Application #
9455789
Study Section
Cellular and Molecular Biology of Glia Study Section (CMBG)
Program Officer
Morris, Jill A
Project Start
2017-09-01
Project End
2019-03-31
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
17
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Advanced Science Research Center
Department
Type
Organized Research Units
DUNS #
831361857
City
New York
State
NY
Country
United States
Zip Code
10031
Ntranos, Achilles; Casaccia, Patrizia (2017) The Microbiome-Gut-Behavior Axis: Crosstalk Between the Gut Microbiome and Oligodendrocytes Modulates Behavioral Responses. Neurotherapeutics :
Motl, Robert W; Mowry, Ellen M; Ehde, Dawn M et al. (2017) Wellness and multiple sclerosis: The National MS Society establishes a Wellness Research Working Group and research priorities. Mult Scler :1352458516687404
Mathur, Deepali; Riffo-Campos, Angela L; Castillo, Josefa et al. (2017) Bioenergetic Failure in Rat Oligodendrocyte Progenitor Cells Treated with Cerebrospinal Fluid Derived from Multiple Sclerosis Patients. Front Cell Neurosci 11:209
Moyon, Sarah; Ma, Dan; Huynh, Jimmy L et al. (2017) Efficient Remyelination Requires DNA Methylation. eNeuro 4:
Zhu, Yunjiao; Vidaurre, Oscar G; Adula, Kadidia P et al. (2017) Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation. J Neurosci 37:7547-7559
Dickens, Alex M; Tovar-Y-Romo, Luis B; Yoo, Seung-Wan et al. (2017) Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions. Sci Signal 10:
Moyon, Sarah; Huynh, Jimmy L; Dutta, Dipankar et al. (2016) Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. Cell Rep :
Liu, Jia; Dupree, Jeffrey L; Gacias, Mar et al. (2016) Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice. J Neurosci 36:957-62
Ntranos, Achilles; Casaccia, Patrizia (2016) Bromodomains: Translating the words of lysine acetylation into myelin injury and repair. Neurosci Lett 625:4-10
Liu, Jia; Moyon, Sarah; Hernandez, Marylens et al. (2016) Epigenetic control of oligodendrocyte development: adding new players to old keepers. Curr Opin Neurobiol 39:133-8

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