Demonstrations of phase shifting and entrainment of human circadian rhythms by timed exposure to artificial bright light have a number of important applications in the treatment of jet lag, shiftwork maladaptation, and other circadian sleep-wake disorders. The long-term objectives of this grant application are to develop a practical and effective means of phase shifting circadian rhythms following transmeridian travel, thereby minimizing the duration and severity of jet lag. Bio-Brite has pioneered the development of a head-mounted Light Visor that is easily carried along on long-distance flights, and that affords the user several advantages over traditional bright light boxes and rooms. Phase I of the project will test the efficacy of a new prototype of the Light Visor in accelerating circadian reentrainment and alleviating jet lag in 20 volunteers following a westward flight across 6 time zones (Zurich-New York). Pre- and post-flight salivary melatonin levels will provide estimates of circadian phase, while actigraphy, performance testing, and subjective scales will provide indices of jet lag severity. These data are expected to lead to further refinements of the Light Visor, and more extensive validation, in Phase II of the project, on groups of travelers following eastward and westward flights across 6-10 time zones.

Proposed Commercial Applications

The International Air Transport Association (LATA) estimated that over 250 million international flights were taken in 1990; many of these involve crossing multiple time zones. Thus, a scientifically validated, practical, and affordable non-drug jet lag treatment program, marketed internationally as a consumer product, can potentially generate annual revenues in the multimillion dollar range.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Small Business Technology Transfer (STTR) Grants - Phase I (R41)
Project #
1R41NS039271-01
Application #
6024048
Study Section
Special Emphasis Panel (ZRG1-IFCN-7 (02))
Program Officer
Nichols, Paul L
Project Start
2000-09-30
Project End
2001-06-30
Budget Start
2000-09-30
Budget End
2001-06-30
Support Year
1
Fiscal Year
2000
Total Cost
$106,612
Indirect Cost
Name
Bio-Brite, Inc.
Department
Type
DUNS #
City
Bethesda
State
MD
Country
United States
Zip Code
20814
Boulos, Ziad; Macchi, M Mila; Sturchler, Matius P et al. (2002) Light visor treatment for jet lag after westward travel across six time zones. Aviat Space Environ Med 73:953-63