The primary objective of this Phase I application is to develop and deploy a novel, neuroplasticity- based, computerized training program that has been shown to drive positive changes in attention, working memory and executive function in a vulnerable aging population. The training approach is based on the scientific principles of brain plasticity, implemented successfully in the past with measurable improvements in cognitive function following intensive training in the elderly (1,26,47). The current approach is fundamentally novel in that it addresses the attentional state of the individual, promoting an optimal level of alertness that can then be applied to higher- order, cognitive abilities. Our data suggests that this approach may enable greater benefits from cognitive training and further generalization to untrained, resource demanding attention, working memory and executive tasks. Given the ease of access to the training regimen and its scalability (web deliverable), this form of therapy could benefit several million individuals, 65-years of age and older whose lives are limited by progressive, age-related cognitive and physical decline.

Public Health Relevance

This project represents the translation of an effective attention training therapy, originally conceived within the academic research sector, to the marketplace via collaboration between the original developers and Brain Plasticity, Inc. This application aims to develop and behaviorally evaluate the benefits of a novel, neuroplasticity-based, computerized and web-deliverable training program suite that has been shown to drive substantial improvements in cognition. These outcomes are widely applicable to the cognitive health and life-quality of several million elderly Americans, and have further potential to offset degenerative processes common to normal aging.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
5R43AG039965-02
Application #
8325537
Study Section
Special Emphasis Panel (ZRG1-ETTN-K (10))
Program Officer
Wagster, Molly V
Project Start
2011-09-01
Project End
2013-09-30
Budget Start
2012-09-01
Budget End
2013-09-30
Support Year
2
Fiscal Year
2012
Total Cost
$345,107
Indirect Cost
Name
Brain Plasticity, Inc.
Department
Type
DUNS #
831447730
City
San Francisco
State
CA
Country
United States
Zip Code
94105