One third of cancer survivors in the United States have undergone abdominopelvic radiation therapy (APRT). Bowel toxicity limits the efficacy of APRT and lowers the quality of life for cancer survivors. The ultimate goal of this program is to develop new approaches to selective protection of the Gl tract from radiation reducing postradiation intestinal dysfunction and improving the lives of a large number of patients. Our proposal is focused on the improvement of therapeutic efficacy of APRT in ovarian cancer model. APRT is widely used as adjuvant therapy in ovarian cancer treatment and prolongs disease-free survival. Dose escalation improves survival but leads to severe bowel toxicity, indicating the possibility to improve survival of patients by mitigation of APRT side effects. Our preliminary studies have shown that flagellin of Salmonella and its optimized derivative delta-FL-AA' act as a powerful radioprotectants of Gl tract acting via Toll-like receptor 5-mediated activation of NF-kappa-B signaling pathway. This protection is selective for normal cells and does not affect radiosensitivity of experimental tumors. Current proposal is devoted to feasibility of this approach in mouse model of ovarian cancer. The success of this work will lay the ground for further developmental steps essential to bringing delta-FL-AA' to clinical trials. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43CA117842-01
Application #
6993464
Study Section
Special Emphasis Panel (ZRG1-DIG-A (10))
Program Officer
Stone, Helen B
Project Start
2005-08-01
Project End
2006-01-31
Budget Start
2005-08-01
Budget End
2006-01-31
Support Year
1
Fiscal Year
2005
Total Cost
$100,000
Indirect Cost
Name
Cleveland Biolabs, Inc.
Department
Type
DUNS #
136769820
City
Buffalo
State
NY
Country
United States
Zip Code
14203