We are developing nanoscale electronic circuits (nanofids) that will be implanted into millions of neurons to record neural activity during behavior. Our long-term goal is to record high-resolution neural activity information during acquisition and expression of learned behavioral models of addiction. The long-term health goal is to identify neuronal ensembles encoding addiction-related memories for eventual ablation. In this application, we are developing semiconductor chip prototypes that will transmit near-infrared (NIR) signals with unique frequency identification whenever intracellular calcium levels rise above a set threshold corresponding to neural activation. We are assessing power requirements and biocompatibility of the overall circuit and individual circuit components in air and intracellular model solutions. Signal attenuation of NIR output will be assessed in these solutions using NIR spectrometry. In future, the optimized circuit from this application will be incorporated into millions of devices that will be implanted into neurons for intracellular recordig of neural activity in brain during behavior.

Public Health Relevance

We are developing nanoscale electronic circuits for large-scale intracellular recording of neural activity during behavior. Our long-term goal is to record high-resolution neural activity information during acquisition and expression of learned behavioral models of addiction. The long-term health goal is to identify neuronal ensembles1 encoding addiction-related memories in human addicts for eventual ablation.

Agency
National Institute of Health (NIH)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43DA038906-01
Application #
8832125
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Bough, Kristopher J
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Galiana Technology, Inc.
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92110