The principal aim of this project is to obtain proof-of-concept for a new nanotechnology-based sensor material for rapid and sensitive fluorescence detection of polycyclic aromatic hydrocarbons (PAHs) and polychloro biphenyls (PCBs). Simple, cheap and safe methods to detect and quantify these toxic substances, which rank high in the ATSDR Substance Priority List and contaminate many US Superfund priority sites, are highly sought after. Emission-based methods using sensitive and specific fluorescent probes offer improved means to do this. Our plan will create new chemosensors useful for detecting and quantifying PAHs and PCBs, including on-site rapid qualitative assays of soil and water of contaminated sites and as analytical probes for the spectrofluorometric quantitization of these high-ranking toxins. In Phase I of this project we will conduct a proof-of-concept study to synthesize new sensor probes and validate their emission properties when challenged with PAH and PCB analytes. The new sensor materials will be useful as rapid and sensitive probes in analytical tests and assays for monitoring the hazardous substances at contaminated Superfund sites.

Public Health Relevance

Toxic polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) pollute Superfund sites in the United States. This research and development project will create new sensor probes to help detect, locate and monitor these toxic chemicals for improved Superfund site cleanup.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43ES022541-01
Application #
8455040
Study Section
Special Emphasis Panel (ZRG1-IMST-S (12))
Program Officer
Henry, Heather F
Project Start
2012-12-10
Project End
2014-11-30
Budget Start
2012-12-10
Budget End
2014-11-30
Support Year
1
Fiscal Year
2013
Total Cost
$150,000
Indirect Cost
Name
Tda Research, Inc.
Department
Type
DUNS #
181947730
City
Wheat Ridge
State
CO
Country
United States
Zip Code
80033