Hematopoietic stem cell transplantation is a form of stem cell therapy used to treat cancers such as lymphoma and leukemia and other blood-related diseases. However, there currently are several drawbacks in the use of bone marrow hematopoietic cell transplantation. Most importantly, the donor pool is limited by the need for at least partial HLA matching, and this delays the finding of a suitable donor. Human umbilical cord blood (hUCB) is increasingly being used as an alternative source of HSC/HPC cells for allogeneic HSCT. However, the absolute number of hUCB HSCs transplanted is much lower than bone marrow cells, and results in significantly delayed engraftment. The proposed studies are to test the efficacy and safety of TAT-SALL4 in reducing the number of hUCB HSCs required for short and long-term engraftments following irradiation, through expansion of HSCs/HPCs in vivo. One of main goals in this proposal is to develop a safe strategy of using a TAT-SALL4 protein for hematopoietic stem cell therapies. Most importantly, our work would greatly impact the field with improved patient outcomes, broader patient usage and possibly lead to the use of just a single umbilical cord for transplantation of HSCs in adults suffering fro acute radiation syndrome, lymphoma, leukemia, or other blood-related diseases.

Public Health Relevance

Our main goals in this proposal are to develop a safe strategy of using a TAT-SALL4 protein for hematopoietic stem cell therapy. Most importantly, our work would greatly impact the field with improved patient outcomes, broader patient usage and possibly lead to the use of just a single cord for transplantation of HSCs in adults suffering from acute radiation syndrome, lymphoma, leukemia, or other blood-related diseases.

Agency
National Institute of Health (NIH)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43HL122000-01A1
Application #
8778976
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Mitchell, Phyllis
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Marrowsource Therapeutics International
Department
Type
DUNS #
City
Setauket
State
NY
Country
United States
Zip Code
11733