Over the last two decades, fMRI has evolved into a widely used technology in basic biobehavioral research. The user base for this technology continues to increase due to the growth of the field of cognitive neuroscience, and this increase is poised to accelerate with adoption of fMRI to large-scale multi-site studies, translational studies, and clinical trials. In order to observe functionally relevant neural responses, it is necessary to conduct experiments in which brain activity is measured while audio/visual stimuli are presented, and behavioral responses are recorded. Further, the software controlling these behavioral experiments must be carefully synchronized with the functioning of the MR scanner itself. Thus, building capacity for fMRI research involves a massive investment in infrastructure for specialized hardware for audio/visual stimulus presentation, behavioral response recording and synchronization of these devices with the MR equipment. And yet, the critical interface between this infrastructure and the software that controls the behavioral experiments, that are the core of the functional assessments in fMRI, is often ad hoc, complicated to use and prone to failure. This creates time-consuming and expensive difficulties at multiple stages of the development and execution of studies, and creates a set of technical problems that are outside the core capabilities and training of the physicists, radiologists and technicians responsible for managing, running and maintaining the MR center. We propose to create a universal software/hardware interface that will dramatically streamline the development and implementation of studies at existing fMRI research sites. The device will provide a sturdy, fixed, standardized, flexible and intuitive interface between a wide variety of experimental control software and all widely used MR systems. Once a minimal viable product is developed, we will test its efficacy in an active fMRI research center.

Public Health Relevance

The lack of a standardized, easy-to-use solution for interfacing fMRI-related hardware and experimental control software is a barrier to the growth of the field of cognitive neuroscience. It also slows the realization of the fMRI's potential for use n clinical trials and the large, multi-site studies that are increasingly understood to be necessary for translational research into key areas relevant to human health. The proposed device will provide a commercial solution to these problems, freeing up the resources currently devoted to developing and maintaining ad hoc solutions, and accelerating the pace of research into basic brain mechanisms underlying cognition, as well as neurobehavioral markers of disease, disorder and response to treatment.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
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Special Emphasis Panel (ZRG1-ETTN-K (10))
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Grabb, Margaret C
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Perception Research Systems, Inc.
United States
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