The main objective of this project is to develop a miniature atmospheric cold plasma brush (m- ACPB) for dental clinical applications. The innovation of this project is the utilization of the recently developed novel non-thermal atmospheric plasma technology for dental treatment to prevent tooth decay and improve the durability and longevity of dental composite restoration. Non-thermal atmospheric plasma is a gaseous medium that is chemically reactive and has the capability to penetrate irregular cavities and fissures and kill bacteria. Furthermore, plasma species can spread up to a few millimeters into a fluid. This feature make non-thermal plasmas extremely suitable to treat, clean, disinfect tooth decay, and fluorinate enamel in a wet oral environment. Plasma treatment of tooth decays or dental surfaces allows us to avoid contamination, actively fight bacterial infections, effectively fluorinate the tooth surfaces, offer additional cleaning to the decayed matters, and prepare/engineer the dental surface for strong and durable bonding to adhesive and sealant materials with a simple plasma treatment process. Such dental clinical applications will be achieved through the development of an m-ACPB that is suitable for dental clinical use.

Public Health Relevance

Nanova, Inc. is developing a miniature atmospheric cold plasma brush (m-ACPB) for dental clinical applications. The innovation of this project is the utilization of the recently developed novel non-thermal atmospheric plasma technology for dental treatment to prevent tooth decay and improve the durability and longevity of dental composite restoration, and could become a high-impact innovation in dentistry.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44DE019041-04
Application #
8286069
Study Section
Special Emphasis Panel (ZRG1-MOSS-N (11))
Program Officer
Drummond, James
Project Start
2008-04-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2012
Total Cost
$558,739
Indirect Cost
Name
Nanova, Inc.
Department
Type
DUNS #
800407343
City
Columbia
State
MO
Country
United States
Zip Code
65203
Dong, Xiaoqing; Chen, Meng; Wang, Yong et al. (2014) A Mechanistic study of Plasma Treatment Effects on Demineralized Dentin Surfaces for Improved Adhesive/Dentin Interface Bonding. Clin Plasma Med 2:11-16
Blumhagen, Adam; Singh, Prashant; Mustapha, Azlin et al. (2014) Plasma deactivation of oral bacteria seeded on hydroxyapatite disks as tooth enamel analogue. Am J Dent 27:84-90
Dong, Xiaoqing; Ritts, Andrew C; Staller, Corey et al. (2013) Evaluation of plasma treatment effects on improving adhesive-dentin bonding by using the same tooth controls and varying cross-sectional surface areas. Eur J Oral Sci 121:355-62