A large, persuasive, and ever-increasing body of evidence links chronic inflammation to virtually all of the chronic diseases that cause the majority of disability and death in the U.S., including diabetes, cardiovascular diseases (CVD), and cancer. Diet plays a central role in the regulation of chronic inflammation. However, until we developed the dietary inflammatory index (DII) there had been no scientifically valid way to relate what individuals eat to the capacity of foods consumed to modulate inflammation. The new generation DII has now produced an impressive research base that ranges from predicting blood levels of inflammatory markers, to clinical conditions associated with inflammation, to a variety of health-related endpoints including cancer incidence and mortality. Connecting Health Innovations (CHI) and our scientific and clinical research partners at the University of South Carolina are committed to translating these research findings to places of clinical need and

Public Health Relevance

Although we know both that chronic, systemic inflammation is linked to virtually all of the chronic diseases that cause the majority of disability and death in he U.S., and that diet plays a central role in the regulation of chronic inflammation, there is virtualy no data linking all three factors. With our development of the dietary inflammatory index (DII) we have been able to fill this void. The work proposed here will allow us to translate an impressive body of evidence-based results linking diet, inflammation, and health-related endpoints to places of clinical need and public health relevance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44DK103377-03
Application #
9043874
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Densmore, Christine L
Project Start
2014-09-04
Project End
2017-03-31
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
3
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Connecting Health Innovations, LLC
Department
Type
DUNS #
078763657
City
Columbia
State
SC
Country
United States
Zip Code
29201
Frith, Emily; Shivappa, Nitin; Mann, Joshua R et al. (2018) Dietary inflammatory index and memory function: population-based national sample of elderly Americans. Br J Nutr 119:552-558
Shivappa, Nitin; Blair, Cindy K; Prizment, Anna E et al. (2018) Dietary inflammatory index and risk of renal cancer in the Iowa Women's Health Study. Eur J Nutr 57:1207-1213
Shivappa, Nitin; Hébert, James R; Paddock, Lisa E et al. (2018) Dietary inflammatory index and ovarian cancer risk in a New Jersey case-control study. Nutrition 46:78-82
Shivappa, Nitin; Hébert, James R; Veronese, Nicola et al. (2018) The relationship between the dietary inflammatory index (DII®) and incident depressive symptoms: A longitudinal cohort study. J Affect Disord 235:39-44
Shivappa, Nitin; R Hébert, James; Jalilpiran, Yahya et al. (2018) Association between Dietary Inflammatory Index and Prostate Cancer in Shiraz Province of Iran Asian Pac J Cancer Prev 19:415-420
Han, Yueh-Ying; Forno, Erick; Shivappa, Nitin et al. (2018) The Dietary Inflammatory Index and Current Wheeze Among Children and Adults in the United States. J Allergy Clin Immunol Pract 6:834-841.e2
Wirth, Michael D; Sevoyan, Maria; Hofseth, Lorne et al. (2018) The Dietary Inflammatory Index is associated with elevated white blood cell counts in the National Health and Nutrition Examination Survey. Brain Behav Immun 69:296-303
Kotsakis, Georgios A; Chrepa, Vanessa; Shivappa, Nitin et al. (2018) Diet-borne systemic inflammation is associated with prevalent tooth loss. Clin Nutr 37:1306-1312
Mazidi, Mohsen; Shivappa, Nitin; Wirth, Michael D et al. (2018) Greater Dietary Inflammatory Index score is associated with higher likelihood of chronic kidney disease. Br J Nutr 120:204-209
Shivappa, Nitin; Hébert, James R; Steck, Susan E et al. (2018) Dietary Inflammatory Index and Odds of Colorectal Cancer in a Case- Control Study from Iran Asian Pac J Cancer Prev 19:1999-2006

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