Giner, Inc. proposes a portable, inexpensive, and rapid-response monitor for arsenic speciation in urine. Arsenic species excreted in urine are reflective of exposure to toxic arsenic species, and therefore this monitor will be a valuable tool in medical diagnostics and epidemiological studies by allowing determination of arsenic exposure by a technique that is faster and less expensive than traditional methods. Improved capability of monitoring exposure will have positive public health outcomes, as long- term exposure to arsenic is associated with health problems including cancer and cardiovascular disease. The phase I program developed a sensor capable of electrochemical detection of arsenic (III), total inorganic arsenic, and dimethylarsenic acid. Total organic arsenic was determined through a sample treatment process followed by electrochemical detection. The phase II program will include further optimization of all methods and processes, design of a prototype device, and validation of the device with real urine samples from epidemiological studies. The phase II program will result in a practical, robust, and accurate arsenic speciation device.

Public Health Relevance

A portable, inexpensive, and rapid-response monitor for speciation analysis of inorganic arsenic and arsenic metabolites in urine is proposed. Traditional methods of assessing arsenic exposure are time- intensive and cost-prohibitive, and therefore such low cost onsite monitor will have positive public health outcomes by improving ability to monitor arsenic exposure in at-risk populations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44ES022313-02
Application #
8714940
Study Section
Special Emphasis Panel (ZRG1-IMST-S (12))
Program Officer
Balshaw, David M
Project Start
2012-09-19
Project End
2016-05-31
Budget Start
2014-06-25
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$510,498
Indirect Cost
Name
Giner, Inc.
Department
Type
DUNS #
066594979
City
Newton
State
MA
Country
United States
Zip Code
02466