There is a need for new technologies to enable the analysis of the protein coding content of a genome. We propose to develop a novel technology for generation and screening of peptide substrates for kinase activity profiling. The technology is designed to enable large scale kinase activity profiling studies.

Public Health Relevance

The kinase substrate screening technology we are developing will help to enable large- scale studies of kinases. This is useful for identifying new drug targets and for drug development. It would help to guide experiments to elucidate the functional roles of specific kinases and may also prove to be a sensitive diagnostic tool, and therefore may result in medical advances in the diagnosis and treatment of disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44GM090392-04
Application #
8546402
Study Section
Special Emphasis Panel (ZRG1-IMST-G (10))
Program Officer
Gerratana, Barbara
Project Start
2010-01-01
Project End
2014-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
4
Fiscal Year
2013
Total Cost
$822,124
Indirect Cost
Name
Prognosys Biosciences, Inc.
Department
Type
DUNS #
170943737
City
San Diego
State
CA
Country
United States
Zip Code
92121