Improved long-term biocompatibility of coronary stents by plasma coating process Abstract Drug-eluting stents (DES) have been widely used to treat patients of cardiac disease due to their better ability to control restenosis than bare metal stents (BMS). However, a serious adverse outcome of late stent thrombosis in patients treated with DES has been reported, which leads to fatal heart attack and death even though it occurs at low rate. Thus, for safe and effective clinical use, a coronary stent needs to have better biocompatibility on its surface that will provide sufficient thrombo-resistance in addition to inhibiting cell proliferation thereby slowing down healing of tissues around the stent. Nanova, Inc. is developing a novel coating layer of high thrombo-resistance on the surface of metallic biomaterials of which coronary stents are made. An environmentally benign technology, low temperature plasma process is used to deposit an ultra-thin (nano-scale) but continuous layer of coating, sufficient to generate desired abrasion resistance and immobilize the bioactive functional groups created in the subsequent plasma surface treatment to prevent blood clots and restenosis, but thin enough to allow for stent expansion without cracking when delivered into patients. The knowledge gained in this innovative research project will also benefit research and development for improved biocompatibility in other implantable medical devices such as pacemakers, pulse generators, cardiac defibrillators and bio-sensors.

Public Health Relevance

Nanova, Inc. is developing a novel coating process on coronary stents to prevent both restenosis of coronary arteries and late in-stent thrombosis (blood clots in stents) for treatment of coronary heart disease, which will benefit over one million of patients in the United States.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
5R44HL097485-03
Application #
8534805
Study Section
Special Emphasis Panel (ZRG1-SBTS-E (10))
Program Officer
Baldwin, Tim
Project Start
2012-08-21
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
3
Fiscal Year
2013
Total Cost
$625,683
Indirect Cost
Name
Nanova, Inc.
Department
Type
DUNS #
800407343
City
Columbia
State
MO
Country
United States
Zip Code
65203
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Jones, John Eric; Yu, Qingsong; Chen, Meng (2017) A chemical stability study of trimethylsilane plasma nanocoatings for coronary stents. J Biomater Sci Polym Ed 28:15-32
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Eric Jones, John; Chen, Meng; Yu, Qingsong (2014) Corrosion resistance improvement for 316L stainless steel coronary artery stents by trimethylsilane plasma nanocoatings. J Biomed Mater Res B Appl Biomater 102:1363-74
Chen, Meng; Yu, Qingsong; Sun, Hongmin (2013) Novel strategies for the prevention and treatment of biofilm related infections. Int J Mol Sci 14:18488-501
Ma, Yibao; Chen, Meng; Jones, John E et al. (2012) Inhibition of Staphylococcus epidermidis biofilm by trimethylsilane plasma coating. Antimicrob Agents Chemother 56:5923-37