Morbidity and mortality of human newborns are significant public health concerns. Group B Streptococci (GBS) are a significant cause of preterm births, stillbirths and early onset sepsis in human newborns. Although GBS normally reside as commensals in the lower genital tract (LGT) of healthy women, the events that promote transmission of GBS from the LGT to the fetus are unknown. Virulence factors important for ascending in utero GBS infections have not been established. Using human placenta and a guinea pig model of intrauterine infection, the objective of this proposal is to define molecular mechanisms that activate virulence gene expression for ascending GBS infection and fetal injury.
Understanding molecular mechanisms that mediate GBS penetration of placenta and fetal organs will be beneficial in therapeutic strategies against infections that lead to fetal injury, preterm births, stillbirths and early onset neonatal infectins.
|Boldenow, Erica; Gendrin, Claire; Ngo, Lisa et al. (2016) GROUP B STREPTOCOCCUS CIRCUMVENTS NEUTROPHILS AND NEUTROPHIL EXTRACELLULAR TRAPS DURING AMNIOTIC CAVITY INVASION AND PRETERM LABOR. Sci Immunol 1:|
|McAdams, Ryan M; Bierle, Craig J; Boldenow, Erica et al. (2015) Choriodecidual Group B Streptococcal Infection Induces miR-155-5p in the Fetal Lung in Macaca nemestrina. Infect Immun 83:3909-17|
|Whidbey, Christopher; Vornhagen, Jay; Gendrin, Claire et al. (2015) A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury. EMBO Mol Med 7:488-505|
|Vornhagen, Jay; Burnside, Kellie; Whidbey, Christopher et al. (2015) Kinase Inhibitors that Increase the Sensitivity of Methicillin Resistant Staphylococcus aureus to Î²-Lactam Antibiotics. Pathogens 4:708-21|
|Gendrin, Claire; Vornhagen, Jay; Ngo, Lisa et al. (2015) Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection. Sci Adv 1:e1400225|
|Gendrin, Claire; Lembo, Annalisa; Whidbey, Christopher et al. (2015) The sensor histidine kinase RgfC affects group B streptococcal virulence factor expression independent of its response regulator RgfA. Infect Immun 83:1078-88|
|Lannon, Sophia M R; Vanderhoeven, Jeroen P; Eschenbach, David A et al. (2014) Synergy and interactions among biological pathways leading to preterm premature rupture of membranes. Reprod Sci 21:1215-27|
|Burnside, Kellie; Lembo, Annalisa; de Los Reyes, Melissa et al. (2010) Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase. PLoS One 5:e11071|