Heart failure is a major public health problem, with limited treatment options. Many patients with heart failure develop mechanical dyssynchrony, with associated further deterioration in heart function. Some patients with heart failure and dyssynchrony benefit from cardiac resynchronization therapy (CRT), but a third or more of heart failure patients selected for treatment with CRT with conventional criteria fail to benefit significantly from it. The primary goals of this project are: 1) development and evaluation of magnetic resonance imaging (MRI) and image analysis methods to better predict outcome of the use of cardiac resynchronization therapy (CRT) for heart failure with dyssynchrony, and 2) use of the imaging-derived data for computer modeling of the effects of the dyssynchrony on cardiac function and its response to CRT. As heart failure is an important clinical condition, and as current means used to predict response to CRT have limited accuracy, this project is potentially clinically very significant.

Public Health Relevance

Heart failure with mechanical dyssynchrony is a relatively common and serious clinical condition;while it may respond to treatment with cardiac resynchronization therapy (CRT), many patients selected for CRT by conventional criteria fail to benefit significantly from it. The goals of this project are to: 1) explore the potential use of magnetic resonance imaging (MRI) data for improved prediction of response to CRT, and 2) use the MRI-derived data together with a computer model of the cardiovascular system to study the relative roles of different factors in the mechanical effects of dyssynchrony in failure, and in th response (or lack thereof) to CRT.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
High Priority, Short Term Project Award (R56)
Project #
1R56HL121750-01
Application #
8916207
Study Section
Special Emphasis Panel (ZRG1-DTCS-A (81))
Program Officer
Desvigne-Nickens, Patrice
Project Start
2014-09-15
Project End
2015-08-31
Budget Start
2014-09-15
Budget End
2015-08-31
Support Year
1
Fiscal Year
2014
Total Cost
$389,453
Indirect Cost
$159,687
Name
New York University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016