The Minnesota Craniofacial Research Training Program is a direct response to PAR-10-170, Institutional Training for a Dental and Craniofacial Research Workforce (T90/R90), and the national need to train the next generation of biomedical scientists to work on significant problems in craniofacial, dental, and oral health research. The mission of the program is to engage trainees in novel, mentored research that is fundamental to biology and human health, and translational research that expands the frontiers and scope of craniofacial, dental, and oral health. To foster our mission and ensure strong mentorship and inter-disciplinary research training, a non-hierarchical and highly consultative administrative structure is in place. The University of Minnesota also serves as a international center for training in craniofacial, dental, and oral health research in partnership with six international dental schools in Europe, Canada and South America. Trainees engage in research training opportunities with groups of experienced, dedicated and well-supported mentors in Neuroscience, Microbiology and Immunology; Cancer Biology; Developmental Biology, Molecular Genetics, and Stem Cells; Biophysical Sciences; Nanotechnology, Materials Sciences, and Tissue Engineering; and Genomics, Proteomics, Structural Biology, and Computational Biology. Trainee T90 programmatic options include DDS/PhD (DSTP), predoctoral PhD, postdoctoral fellows, and R90 postdoctoral PhD for international dental clinicians. For non-clinician PhDs, a new program in Oral Pathobiology has been created, providing basic mechanisms with clinical correlates and hypothesis generation. The Minnesota Craniofacial Research Training program builds upon our considerable training experience, outstanding applicant pools and partnerships, new initiatives to recruit and retain DSTP fellows, and appreciation for creative mentored research training. Our alumni work at the state-of-the-art to expand the frontiers of biology and craniofacial, dental, and oral health research.

Public Health Relevance

The Minnesota Craniofacial Research Training Program is a direct response to PAR-10-170. The program will continue to engage trainees in novel, mentored research training that is fundamental to biology and human health, and translational research that expands the frontiers and scope of craniofacial, dental, and oral health. Trainee T90 programmatic options include DDS/PhD (DSTP), predoctoral PhD, postdoctoral fellows, and R90 postdoctoral PhD for international dental clinicians. For non-clinician PhDs, a new program in Oral Pathobiology has been created, providing basic mechanisms with clinical correlates and hypothesis generation. Our alumni work at the state-of-the-art to expand the frontiers of biology and craniofacial, dental, and oral health research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Interdisciplinary Regular Research Training Award (R90)
Project #
4R90DE023058-05
Application #
9081579
Study Section
Special Emphasis Panel (ZDE1)
Program Officer
King, Lynn M
Project Start
2012-07-01
Project End
2017-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
5
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Engineering (All Types)
Type
Schools of Dentistry/Oral Hygn
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Argyris, P P; Slama, Z M; Ross, K F et al. (2018) Calprotectin and the Initiation and Progression of Head and Neck Cancer. J Dent Res 97:674-682
Harmouche, Nicole; Aisenbrey, Christopher; Porcelli, Fernando et al. (2017) Solution and Solid-State Nuclear Magnetic Resonance Structural Investigations of the Antimicrobial Designer Peptide GL13K in Membranes. Biochemistry 56:4269-4278
Kidwai, Fahad; Edwards, Jessica; Zou, Li et al. (2016) Fibrinogen Induces RUNX2 Activity and Osteogenic Development from Human Pluripotent Stem Cells. Stem Cells 34:2079-89
Li, Yuping; Chen, Xi; Fok, Alex et al. (2015) Biomimetic Mineralization of Recombinamer-Based Hydrogels toward Controlled Morphologies and High Mineral Density. ACS Appl Mater Interfaces 7:25784-92
Billington Jr, Charles J; Schmidt, Brian; Marcucio, Ralph S et al. (2015) Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice. Dis Model Mech 8:139-46
Zou, Li; Kidwai, Fahad K; Kopher, Ross A et al. (2015) Use of RUNX2 expression to identify osteogenic progenitor cells derived from human embryonic stem cells. Stem Cell Reports 4:190-8
Chen, YungChung; Fok, Alex (2014) Stress distributions in human teeth modeled with a natural graded material distribution. Dent Mater 30:e337-48
Silva, Emmanuel J; Argyris, Prokopios P; Zou, Xianqiong et al. (2014) S100A8/A9 regulates MMP-2 expression and invasion and migration by carcinoma cells. Int J Biochem Cell Biol 55:279-87
Chen, Xi; Hirt, Helmut; Li, Yuping et al. (2014) Antimicrobial GL13K peptide coatings killed and ruptured the wall of Streptococcus gordonii and prevented formation and growth of biofilms. PLoS One 9:e111579
Billington Jr, Charles J; Schmidt, Brian; Zhang, Lei et al. (2013) Maternal diet supplementation with methyl donors and increased parity affect the incidence of craniofacial defects in the offspring of twisted gastrulation mutant mice. J Nutr 143:332-9

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