This application addresses broad Challenge Area (13) Smart Biomaterials-Theranostics and specific Challenge Topic, 13-DE-102: Dental Resin Composite and Caries. It is known that half of all dental restorations fail within 10 years and replacing them consumes 60% of the average dentist's practice time. Secondary caries and fracture of the restoration are found to be the main reasons for restoration failure. To face these challenges, dental restoratives must be made strong and stable enough to withstand fracture and wear, and antibacterial enough to prevent or reduce secondary caries. The overall goal of this research project is to develop a novel high-performance biocompatible glass-ionomer cement (GIC) system with permanent antibacterial function to combat bacterial destruction, prevent biofilm formation and withstand fracture and wear for enhancing restoration longevity. Currently, none of the commercially available GICs are being used for high stress- and high wear-bearing restorations as are composite resins, due to their poor wear-resistance and low mechanical strengths, although these cements have numerous advantages over composite resins. Furthermore, none of the dental restoratives are permanently antibacterial, which significantly increases the incidence of secondary caries. We have demonstrated that novel star-shaped polyacid-constructed resin-modified GIC (RMGIC) exhibited outstanding and comparable wear-resistance as well as mechanical strengths to some of the current composite resins, in addition to its inherent adhesion to tooth that composite resins do not have. In this challenge proposal, we propose to develop a novel antibacterial and biocompatible high-performance RMGIC system constructed with well- designed highly-branched polymers along with covalently attached quaternary ammonium cations (Quats) for stronger and longer-lasting restoration as well as secondary cavity prevention or reduction. This system is uniquely designed to combine all the major advantages but minimize the disadvantages that composite resins, conventional GICs and RMGICs have. In this research, a series of well-designed as well as well- constructed highly-branched polymers and a series of new antibacterial Quats will be synthesized and used to formulate a high-performance GIC system with permanent antibacterial function. Flexural strength, wear- resistance and viscosity will be used as primary screening tools for cement formulation and optimization. Bactericidal testing against Streptococcus mutans will be used as a primary screening tool for Quat's antibacterial evaluation. Important mechanical properties, physical properties, in vitro antibacterial activity and in vitro biocompatibility of the optimal system will be evaluated. Successful achievement of the goals of this project will positively impact the fields of restorative, preventive and minimally invasive dentistry and early caries intervention by providing a new attractive antibacterial adhesive dental restorative. Secondary caries and fracture of the restoration are found to be the main reasons for dental restoration failure. To face these challenges, dental restoratives must be made strong and stable enough to withstand fracture and wear, and antibacterial enough to prevent or reduce secondary caries. The objective of this research is to develop a novel high-performance biocompatible glass-ionomer cement system with permanent antibacterial function to combat bacterial destruction, prevent biofilm formation and withstand fracture and wear for enhancing restoration longevity.

Public Health Relevance

Secondary caries and fracture of the restoration are found to be the main reasons for dental restoration failure. To face these challenges, dental restoratives must be made strong and stable enough to withstand fracture and wear, and antibacterial enough to prevent or reduce secondary caries. The objective of this research is to develop a novel high-performance biocompatible glass-ionomer cement system with permanent antibacterial function to combat bacterial destruction, prevent biofilm formation and withstand fracture and wear for enhancing restoration longevity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
NIH Challenge Grants and Partnerships Program (RC1)
Project #
5RC1DE020614-02
Application #
7933990
Study Section
Special Emphasis Panel (ZRG1-MOSS-C (58))
Program Officer
Drummond, James
Project Start
2009-09-17
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2012-08-31
Support Year
2
Fiscal Year
2010
Total Cost
$398,990
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Howard, Leah; Weng, Yiming; Xie, Dong (2014) Preparation and evaluation of a novel star-shaped polyacid-constructed dental glass-ionomer system. Dent Mater 30:644-53
Weng, Y; Howard, L; Xie, D (2014) A novel star-shaped poly(carboxylic acid) for resin-modified glass-ionomer restoratives. J Biomater Sci Polym Ed 25:1076-90
Li, Mingyun; Huang, Ruijie; Zhou, Xuedong et al. (2014) Effect of nicotine on dual-species biofilms of Streptococcus mutans and Streptococcus sanguinis. FEMS Microbiol Lett 350:125-32
Li, Ming-Yun; Huang, Rui-Jie; Zhou, Xue-Dong et al. (2013) Role of sortase in Streptococcus mutans under the effect of nicotine. Int J Oral Sci 5:206-11
Huang, Ruijie; Li, Mingyun; Gregory, Richard L (2012) Effect of nicotine on growth and metabolism of Streptococcus mutans. Eur J Oral Sci 120:319-25
Weng, Yiming; Howard, Leah; Guo, Xia et al. (2012) A novel antibacterial resin composite for improved dental restoratives. J Mater Sci Mater Med 23:1553-61
Weng, Yiming; Howard, Leah; Chong, Voon Joe et al. (2012) A novel furanone-modified antibacterial dental glass ionomer cement. Acta Biomater 8:3153-60
Huang, Ruijie; Li, Mingyun; Gregory, Richard L (2011) Bacterial interactions in dental biofilm. Virulence 2:435-44
Xie, Dong; Weng, Yiming; Guo, Xia et al. (2011) Preparation and evaluation of a novel glass-ionomer cement with antibacterial functions. Dent Mater 27:487-96
Zhao, Jun; Xie, Dong (2011) A novel hyperbranched poly(acrylic acid) for improved resin-modified glass-ionomer restoratives. Dent Mater 27:478-86

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