We propose the replacement of a 12-year-old GE (Signa LX) MRI console with a state-of-the-art Varian/Agilent console to support magnetic resonance microscopy for scientists throughout the world. Coupled to an existing 9.4T magnet and a new generation of cryogenic rf probe, this truly unique imaging system will support spatial resolution at the diffusion limit (<10 micrometers). A novel diffusion tensor imaging strategy will provide routine imaging with isotropic spatial resolution <20 micrometers. This resource will support the work of 18 NIH-funded investigators with 27 NIH grants. The system will allow us to increase the throughput for routine magnetic resonance microscopy by more than 3 times;increase the spatial resolution over limited fields by nearly 10 times;and reduce the scan time for diffusion tensor microscopy by at least 4 times.

Public Health Relevance

Sequencing of the human genome has opened an entirely new era of molecular medicine, and one of the most critical issues faced is connecting the vast information in the sequenced human genome to the physical expression-the phenotype. Mouse models are one a critical vehicles to this understanding. Magnetic resonance histology will be used to understand changes in brain morphology of a number of the most critical models, helping connect genotype to phenotype.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10OD010683-01
Application #
8247218
Study Section
Special Emphasis Panel (ZRG1-SBIB-W (30))
Program Officer
Levy, Abraham
Project Start
2012-05-15
Project End
2013-11-14
Budget Start
2012-05-15
Budget End
2013-11-14
Support Year
1
Fiscal Year
2012
Total Cost
$596,700
Indirect Cost
Name
Duke University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705