This revised application requests funds to purchase a TR19 dual particle cyclotron manufactured by Advance Cyclotron Systems which is necessary to support ongoing and future research growth at Washington University. The combination of features within the TR19 is optimal for supporting the diverse number of PET radionuclides and radiopharmaceuticals needed to support our NIH-funded research. The TR19 which is the only machine suitable to produce a broad spectrum of positron-emitting isotopes including Cu-64, Zr-89, I-124;it is also ideal for increasing the production of "standard" radionuclides such as C-11, F-18, an O-15 required for our clinical imaging studies. The TR19 will be installed in the Department of Radiology at Washington University (WU). WU has ongoing inpatient and outpatient research near this location that offers unique clinical and collaborative research projects. The TR19 will fulfill the long-term objective to increase our ability to support ongoing and future research growth at Washington University by providing a more reliable and flexible platform that will double the radioisotope production capacity of our cyclotron facility. By significantly enhancing our reliability to produce radioisotopes, PET research can continue without concern of complications due to frequent and severe maintenance issues leading to unavoidable downtown and the cancellation of research studies. Unlike the current CS-15 and JSW168 cyclotrons, the TR19 will allow increased efficiency and flexibility for non-standard isotope production as well as improved production capabilities of the standard PET radionuclides.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10OD012252-01A1
Application #
8334887
Study Section
Special Emphasis Panel (ZRG1-SBIB-X (30))
Program Officer
Levy, Abraham
Project Start
2012-08-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2014-07-31
Support Year
1
Fiscal Year
2012
Total Cost
$2,000,000
Indirect Cost
Name
Washington University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130