Echo MRI-100(tm) 3-in-1 Obesity is a problem with increasing impact on human health and at present more than 60% of the population in the U.S. is either frankly obese or overweight. Despite the prevalence of this problem there are few effective treatments. Mouse models have provided valuable insights into understanding pathways important in the development of human obesity. This includes understanding both molecular pathways and the effects of dietary induced obesity. Analysis of mouse models requires technical capacity to evaluate body composition, particularly adiposity. The technology currently available to the group of obesity researchers at the BIDMC division of Endocrinology has significant limitations. Acquisition of the requested EchoMRI 3-in-1 will bypass this limitation and enhance ability to perform studies and also decrease the size of cohorts required. In addition this equipment will provide a heretofore unavailable capacity to evaluate composition of tissue samples, either from rodents or from human biopsy samples. Because of the capacity of the equipment, in addition to projected significant use by BIDMC Endocrine faculty and their collaborators the service can be offered to other BIDMC investigators. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR023791-01
Application #
7221653
Study Section
Special Emphasis Panel (ZRG1-SBIB-N (30))
Program Officer
Tingle, Marjorie
Project Start
2007-04-01
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
1
Fiscal Year
2007
Total Cost
$110,000
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
Douris, Nicholas; Melman, Tamar; Pecherer, Jordan M et al. (2015) Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. Biochim Biophys Acta 1852:2056-65