This is a proposal to support the purchase of a Scanco CT100 specimen micro computed tomography scanner (

Public Health Relevance

Three-dimensional micro-computed tomography (?CT) has become a critically important standard technology in musculoskeletal and tissue engineering research. Use of this technology has greatly accelerated advances in the understanding of bone disease and the development of strategies for engineering functional tissues by providing quantitative measures of bone responses to physiologic, biologic, mechanical, pharmacologic or disease related influences. Since its introduction into biomedical research, this radiographic based tomographic technology, along with the development of computer reconstruction algorithms, has provided the capability to characterize bone structure as it had never been characterized before. As a result, ?CT has had a significant impact on musculoskeletal health. This is a proposal to support the purchase of a Scanco CT100 specimen ?CT system that is to be part of an Imaging Core Facility at the University of Michigan School of Dentistry and shared with other users in the Schools of Medicine, Engineering and Literature, Arts and Sciences. The requested instrument will fulfill an unmet need for ?CT at the University by providing increased throughput, increased resolution and ability to analyze denser materials, enabling NIH-funded users to make further advances in health related research.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR026475-01
Application #
7793129
Study Section
Special Emphasis Panel (ZRG1-SBIB-D (30))
Program Officer
Birken, Steven
Project Start
2009-12-31
Project End
2011-12-30
Budget Start
2009-12-31
Budget End
2011-12-30
Support Year
1
Fiscal Year
2010
Total Cost
$380,800
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Biology
Type
Schools of Dentistry
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Pan, Haichun; Zhang, Honghao; Abraham, Ponnu et al. (2017) BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development. Dev Biol 429:260-270
Shi, Ce; Mandair, Gurjit S; Zhang, Honghao et al. (2017) Bone morphogenetic protein signaling through ACVR1 and BMPR1A negatively regulates bone mass along with alterations in bone composition. J Struct Biol :
Cawthorn, William P; Scheller, Erica L; Parlee, Sebastian D et al. (2016) Expansion of Bone Marrow Adipose Tissue During Caloric Restriction Is Associated With Increased Circulating Glucocorticoids and Not With Hypoleptinemia. Endocrinology 157:508-21
Zhang, Yanshuai; McNerny, Erin Gatenby; Terajima, Masahiko et al. (2016) Loss of BMP signaling through BMPR1A in osteoblasts leads to greater collagen cross-link maturation and material-level mechanical properties in mouse femoral trabecular compartments. Bone 88:74-84
Shi, Ce; Iura, Ayaka; Terajima, Masahiko et al. (2016) Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors. Sci Rep 6:24256
Zhang, Honghao; Takeda, Haruko; Tsuji, Takehito et al. (2015) Generation of Evc2/Limbin global and conditional KO mice and its roles during mineralized tissue formation. Genesis :
Lamia, Arthur F; McDonald, N J (2015) Microcomputed tomographic evaluation of mandibular molars with single distal canals. Gen Dent 63:33-7
Iura, Ayaka; McNerny, Erin Gatenby; Zhang, Yanshuai et al. (2015) Mechanical Loading Synergistically Increases Trabecular Bone Volume and Improves Mechanical Properties in the Mouse when BMP Signaling Is Specifically Ablated in Osteoblasts. PLoS One 10:e0141345
Yang, Jie; Wang, Shih-Kai; Choi, Murim et al. (2015) Taurodontism, variations in tooth number, and misshapened crowns in Wnt10a null mice and human kindreds. Mol Genet Genomic Med 3:40-58
Kuroshima, Shinichiro; Mecano, Rodan B; Tanoue, Ryuichiro et al. (2014) Distinctive tooth-extraction socket healing: bisphosphonate versus parathyroid hormone therapy. J Periodontol 85:24-33

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