This is a proposal to support the purchase of a Scanco CT100 specimen micro computed tomography scanner ( Three-dimensional micro-computed tomography (?CT) has become a critically important standard technology in musculoskeletal and tissue engineering research. Use of this technology has greatly accelerated advances in the understanding of bone disease and the development of strategies for engineering functional tissues by providing quantitative measures of bone responses to physiologic, biologic, mechanical, pharmacologic or disease related influences. Since its introduction into biomedical research, this radiographic based tomographic technology, along with the development of computer reconstruction algorithms, has provided the capability to characterize bone structure as it had never been characterized before. As a result, ?CT has had a significant impact on musculoskeletal health. This is a proposal to support the purchase of a Scanco CT100 specimen ?CT system that is to be part of an Imaging Core Facility at the University of Michigan School of Dentistry and shared with other users in the Schools of Medicine, Engineering and Literature, Arts and Sciences. The requested instrument will fulfill an unmet need for ?CT at the University by providing increased throughput, increased resolution and ability to analyze denser materials, enabling NIH-funded users to make further advances in health related research.Public Health Relevance
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