Funds are requested to purchase an atomic force microscope (AFM) in order to establish the Core Laboratory for Biomedical Applications of Atomic Force Microscopy at the University of Virginia. The instrument purchased will be the Multimode V Scanning Probe Microscope with Nanoscope V SPM Control Station from Veeco Metrology, Inc., in Santa Barbara, CA. Accessories will be purchased to allow imaging of biological samples under physiological buffer and temperature conditions. The Core Laboratory will be centrally located in the School of Medicine and will be used by researchers from the Departments of Biochemistry and Molecular Genetics, Pharmacology, Molecular Physiology and Biological Physics, Microbiology, and Medicine in the School of Medicine, and from the Departments of Chemistry and Biology in the College of Arts and Sciences. The major common research themes will involve signaling processes in or on model membrane systems and the dynamics and structure of macromolecular complexes. The processes that will be studied with this instrument are fundamental to the molecular basis of cancer, endocrine disorders, neuropathology, bacterial infection, and growth and development. The Core Laboratory will be directed by an experienced AFM researcher and an interdepartmental advisory committee, and will provide training and outreach activities to enhance the utilization of the AFM in NIH-funded biomedical research programs at the University.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR026490-01
Application #
7792772
Study Section
Special Emphasis Panel (ZRG1-OBT-A (30))
Program Officer
Levy, Abraham
Project Start
2010-05-13
Project End
2011-05-12
Budget Start
2010-05-13
Budget End
2011-05-12
Support Year
1
Fiscal Year
2010
Total Cost
$203,250
Indirect Cost
Name
University of Virginia
Department
Pharmacology
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904