This application is for acquisition of a micro X-ray computed tomograph (MicroXCT-200). Recent advances in computed tomography open new opportunities for biomaterials and bioengineering research. The developments of microCTs allow high resolution imaging of internal structures of mineralized tissues and their interfaces with soft tissues down to 1

Public Health Relevance

This grant requests new high magnification non-invasive imaging equipment to support critical work of a number of NIH supported investigators who are working in the areas of dental and bone disease and the development of treatments that will minimize needed surgery, new diagnostic procedures for dental decay, and tissue engineering and stem cells to aid in regeneration of dental, oral, and skeletal issues.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR026645-01
Application #
7793331
Study Section
Special Emphasis Panel (ZRG1-SBIB-D (30))
Program Officer
Birken, Steven
Project Start
2010-07-15
Project End
2011-07-14
Budget Start
2010-07-15
Budget End
2011-07-14
Support Year
1
Fiscal Year
2010
Total Cost
$500,000
Indirect Cost
Name
University of California San Francisco
Department
Dentistry
Type
Schools of Dentistry
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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Hsi, Ryan S; Ramaswamy, Krishna; Ho, Sunita P et al. (2017) The origins of urinary stone disease: upstream mineral formations initiate downstream Randall's plaque. BJU Int 119:177-184
Naveau, Adrien; Zhang, Bin; Meng, Bo et al. (2017) Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res 32:2219-2231
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Du, Jing; Lee, Ji-Hyun; Jang, Andrew T et al. (2015) Biomechanics and strain mapping in bone as related to immediately-loaded dental implants. J Biomech 48:3486-94
Djomehri, Sabra I; Candell, Susan; Case, Thomas et al. (2015) Mineral density volume gradients in normal and diseased human tissues. PLoS One 10:e0121611

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