This proposal requests funds for the acquisition of a 500 MHz NMR spectrometer with a triple resonance probe. To maximize utility across a multidisciplinary user base, the instrument will be equipped with an autosampler and will be networked to the broader campus community. The proposed instrument will replace a routine use 360 MHz spectrometer that is nearly 20 years old. The new spectrometer will serve to meet the routine need for high resolution NMR spectroscopy that has become essential to many research groups at UD. The new triple channel spectrometer will also enable a range of multinuclear experiments (15N to 31P) that currently cannot be carried out on any of the spectrometers in the UD NMR facility. The proposed instrument will provide benefit to a large user base of NIH supported researchers that spans the areas of organic chemistry, inorganic chemistry, bioorganic chemistry, biochemistry, materials science, physics and biological sciences. Projects to be facilitated by this grant will have impact on the nation's health interests in drug discovery, radiochemical imaging, cancer therapy, tissue regeneration and drug delivery. Descriptions of eight research projects by nine major users of the proposed instrumentation are described. All nine major users are investigators on currently funded NIH supported research projects. Beyond the major user group, the 500 MHz NMR spectrometer will also support the research efforts of more than 20 additional faculty members at UD. This instrumentation will also provide substantive support to several major NIH initiatives centered at the University of Delaware, including a Chemistry Biology Interface (CBI) Program, two Centers of Biomedical Research Excellence (COBRE), the Delaware IDeA Network of Biomedical Research Excellence (INBRE), and a Center for Translational Cancer Research.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-BCMB-N (30))
Program Officer
Levy, Abraham
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Delaware
Schools of Arts and Sciences
United States
Zip Code
Cinderella, Andrew P; Vulovic, Bojan; Watson, Donald A (2017) Palladium-Catalyzed Cross-Coupling of Silyl Electrophiles with Alkylzinc Halides: A Silyl-Negishi Reaction. J Am Chem Soc 139:7741-7744
Lambert, William D; Scinto, Samuel L; Dmitrenko, Olga et al. (2017) Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling. Org Biomol Chem 15:6640-6644
Rezazadeh, Sina; Devannah, Vijayarajan; Watson, Donald A (2017) Nickel-Catalyzed C-Alkylation of Nitroalkanes with Unactivated Alkyl Iodides. J Am Chem Soc 139:8110-8113
Gietter-Burch, Amber A S; Devannah, Vijayarajan; Watson, Donald A (2017) Trifluoromethylation of Secondary Nitroalkanes. Org Lett 19:2957-2960
Basch, Corey H; Cobb, Kelsey M; Watson, Mary P (2016) Nickel-Catalyzed Borylation of Benzylic Ammonium Salts: Stereospecific Synthesis of Enantioenriched Benzylic Boronates. Org Lett 18:136-9
Panish, Robert A; Chintala, Srinivasa R; Fox, Joseph M (2016) A Mixed-Ligand Chiral Rhodium(II) Catalyst Enables the Enantioselective Total Synthesis of Piperarborenine?B. Angew Chem Int Ed Engl 55:4983-7
Wang, Mengzhe; Svatunek, Dennis; Rohlfing, Katarina et al. (2016) Conformationally Strained trans-Cyclooctene (sTCO) Enables the Rapid Construction of (18)F-PET Probes via Tetrazine Ligation. Theranostics 6:887-95
Zhang, Han; Trout, William S; Liu, Shuang et al. (2016) Rapid Bioorthogonal Chemistry Turn-on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation. J Am Chem Soc 138:5978-83
Shuler, Scott A; Yin, Guoyin; Krause, Sarah B et al. (2016) Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction. J Am Chem Soc :
DeAngelis, Andrew; Panish, Robert; Fox, Joseph M (2016) Rh-Catalyzed Intermolecular Reactions of ?-Alkyl-?-Diazo Carbonyl Compounds with Selectivity over ?-Hydride Migration. Acc Chem Res 49:115-27

Showing the most recent 10 out of 29 publications