In this proposal, a group of six faculty members in the Division of Chemistry and Chemical Engineering at the California Institute of Technology are requesting a shared 400 MHz nuclear magnetic resonance spectrometer. All are synthetic organic chemists;all but one (a recently hired assistant professor) have NIH funding. Three of the investigators (Grubbs, Reisman, Stoltz) have a strong focus on methodology;the others (Dervan, Dougherty, Hsieh-Wilson) have a more bio-organic focus. The requested instrument is intended to be a faster, more capable, and modern replacement for an antiquated 300 MHz instrument used for immediate characterization of newly synthesized compounds. It would be placed in a core facility where more than 50,000 spectra are acquired annually, but four of the seven instruments are 300 MHz spectrometers poorly matched to the needs of modern research at Caltech, and two of the three higher field instruments are quite old. The requested instrument would be a key component of a revitalized core facility at Caltech.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-BCMB-N (30))
Program Officer
Birken, Steven
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
California Institute of Technology
Schools of Engineering
United States
Zip Code
Dornan, Peter K; Lee, Daniel; Grubbs, Robert H (2016) Tandem Olefin Metathesis/Oxidative Cyclization: Synthesis of Tetrahydrofuran Diols from Simple Olefins. J Am Chem Soc 138:6372-5
Daniels, Blake E; Ni, Jane; Reisman, Sarah E (2016) Synthesis of Enantioenriched Indolines by a Conjugate Addition/Asymmetric Protonation/Aza-Prins Cascade Reaction. Angew Chem Int Ed Engl 55:3398-402
Dornan, Peter K; Wickens, Zachary K; Grubbs, Robert H (2015) Tandem Z-Selective Cross-Metathesis/Dihydroxylation: Synthesis of anti-1,2-Diols. Angew Chem Int Ed Engl 54:7134-8
Bronner, Sarah M; Grubbs, Robert H (2014) Formal Anti-Markovnikov Hydroamination of Terminal Olefins. Chem Sci 5:
Hartung, John; Dornan, Peter K; Grubbs, Robert H (2014) Enantioselective olefin metathesis with cyclometalated ruthenium complexes. J Am Chem Soc 136:13029-37
Shockley, Samantha E; Holder, Jeffrey C; Stoltz, Brian M (2014) A catalytic, enantioselective formal synthesis of (+)-dichroanone and (+)-taiwaniaquinone H. Org Lett 16:6362-5
Cannon, Jeffrey S; Zou, Lufeng; Liu, Peng et al. (2014) Carboxylate-assisted C(spĀ³)-H activation in olefin metathesis-relevant ruthenium complexes. J Am Chem Soc 136:6733-43
Mangold, Shane L; O'Leary, Daniel J; Grubbs, Robert H (2014) Z-Selective olefin metathesis on peptides: investigation of side-chain influence, preorganization, and guidelines in substrate selection. J Am Chem Soc 136:12469-78
Wang, Haoxuan; Reisman, Sarah E (2014) Enantioselective total synthesis of (-)-lansai B and (+)-nocardioazines A and B. Angew Chem Int Ed Engl 53:6206-10
Bronner, Sarah M; Herbert, Myles B; Patel, Paresma R et al. (2014) Ru-Based Z-Selective Metathesis Catalysts with Modified Cyclometalated Carbene Ligands. Chem Sci 5:4091-4098

Showing the most recent 10 out of 41 publications