In this proposal, a group of six faculty members in the Division of Chemistry and Chemical Engineering at the California Institute of Technology are requesting a shared 400 MHz nuclear magnetic resonance spectrometer. All are synthetic organic chemists;all but one (a recently hired assistant professor) have NIH funding. Three of the investigators (Grubbs, Reisman, Stoltz) have a strong focus on methodology;the others (Dervan, Dougherty, Hsieh-Wilson) have a more bio-organic focus. The requested instrument is intended to be a faster, more capable, and modern replacement for an antiquated 300 MHz instrument used for immediate characterization of newly synthesized compounds. It would be placed in a core facility where more than 50,000 spectra are acquired annually, but four of the seven instruments are 300 MHz spectrometers poorly matched to the needs of modern research at Caltech, and two of the three higher field instruments are quite old. The requested instrument would be a key component of a revitalized core facility at Caltech.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR027690-01
Application #
7795621
Study Section
Special Emphasis Panel (ZRG1-BCMB-N (30))
Program Officer
Birken, Steven
Project Start
2009-11-26
Project End
2010-11-25
Budget Start
2009-11-26
Budget End
2010-11-25
Support Year
1
Fiscal Year
2010
Total Cost
$315,427
Indirect Cost
Name
California Institute of Technology
Department
Chemistry
Type
Schools of Engineering
DUNS #
009584210
City
Pasadena
State
CA
Country
United States
Zip Code
91125
Dornan, Peter K; Lee, Daniel; Grubbs, Robert H (2016) Tandem Olefin Metathesis/Oxidative Cyclization: Synthesis of Tetrahydrofuran Diols from Simple Olefins. J Am Chem Soc 138:6372-5
Daniels, Blake E; Ni, Jane; Reisman, Sarah E (2016) Synthesis of Enantioenriched Indolines by a Conjugate Addition/Asymmetric Protonation/Aza-Prins Cascade Reaction. Angew Chem Int Ed Engl 55:3398-402
Dornan, Peter K; Wickens, Zachary K; Grubbs, Robert H (2015) Tandem Z-Selective Cross-Metathesis/Dihydroxylation: Synthesis of anti-1,2-Diols. Angew Chem Int Ed Engl 54:7134-8
Bronner, Sarah M; Grubbs, Robert H (2014) Formal Anti-Markovnikov Hydroamination of Terminal Olefins. Chem Sci 5:
Hartung, John; Dornan, Peter K; Grubbs, Robert H (2014) Enantioselective olefin metathesis with cyclometalated ruthenium complexes. J Am Chem Soc 136:13029-37
Shockley, Samantha E; Holder, Jeffrey C; Stoltz, Brian M (2014) A catalytic, enantioselective formal synthesis of (+)-dichroanone and (+)-taiwaniaquinone H. Org Lett 16:6362-5
Cannon, Jeffrey S; Zou, Lufeng; Liu, Peng et al. (2014) Carboxylate-assisted C(spĀ³)-H activation in olefin metathesis-relevant ruthenium complexes. J Am Chem Soc 136:6733-43
Mangold, Shane L; O'Leary, Daniel J; Grubbs, Robert H (2014) Z-Selective olefin metathesis on peptides: investigation of side-chain influence, preorganization, and guidelines in substrate selection. J Am Chem Soc 136:12469-78
Wang, Haoxuan; Reisman, Sarah E (2014) Enantioselective total synthesis of (-)-lansai B and (+)-nocardioazines A and B. Angew Chem Int Ed Engl 53:6206-10
Bronner, Sarah M; Herbert, Myles B; Patel, Paresma R et al. (2014) Ru-Based Z-Selective Metathesis Catalysts with Modified Cyclometalated Carbene Ligands. Chem Sci 5:4091-4098

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