Abstract

This proposal is for a Synapt ion mobility mass spectrometer and will be used for the characterization of therapeutics. The instrument is also used to characterize the effect of therapeutics on cellular processes and cell-to cell communication. This equipment will be used to train the future generation of Doctors of Pharmacy and PhD students engaged in drug development. Finally, the Synapt ion mobility mass spectrometer enables the discovery of the next generation therapeutics and therapeutic targets.

Public Health Relevance

This proposal is requesting funds for a mass spectrometry instrument that is to be used to uncover targets of disease and the discovery and characterization of novel therapeutics.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR029121-01
Application #
7842443
Study Section
Special Emphasis Panel (ZRG1-BCMB-K (30))
Program Officer
Levy, Abraham
Project Start
2011-06-15
Project End
2012-06-14
Budget Start
2011-06-15
Budget End
2012-06-14
Support Year
1
Fiscal Year
2011
Total Cost
$802,398
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Schools of Pharmacy
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Puri, Aaron W; Mevers, Emily; Ramadhar, Timothy R et al. (2018) Tundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism. J Am Chem Soc 140:2002-2006
Tripathi, Anupriya; Melnik, Alexey V; Xue, Jin et al. (2018) Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome. mSystems 3:
Patin, Nastassia V; Floros, Dimitrios J; Hughes, Chambers C et al. (2018) The role of inter-species interactions in Salinispora specialized metabolism. Microbiology 164:946-955
Quinn, Robert A; Comstock, William; Zhang, Tianyu et al. (2018) Niche partitioning of a pathogenic microbiome driven by chemical gradients. Sci Adv 4:eaau1908
Mohimani, Hosein; Gurevich, Alexey; Mikheenko, Alla et al. (2017) Dereplication of peptidic natural products through database search of mass spectra. Nat Chem Biol 13:30-37
Caraballo-Rodríguez, Andrés M; Dorrestein, Pieter C; Pupo, Monica T (2017) Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides. Sci Rep 7:5373
Floros, Dimitrios J; Petras, Daniel; Kapono, Clifford A et al. (2017) Mass Spectrometry Based Molecular 3D-Cartography of Plant Metabolites. Front Plant Sci 8:429
McCall, Laura-Isobel; Morton, James T; Bernatchez, Jean A et al. (2017) Mass Spectrometry-Based Chemical Cartography of a Cardiac Parasitic Infection. Anal Chem 89:10414-10421
Shalapour, Shabnam; Lin, Xue-Jia; Bastian, Ingmar N et al. (2017) Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature 551:340-345
Floros, Dimitrios J; Jensen, Paul R; Dorrestein, Pieter C et al. (2016) A metabolomics guided exploration of marine natural product chemical space. Metabolomics 12:

Showing the most recent 10 out of 41 publications