This application requests funding to support the purchase of a state-of-the-art PET-SPECT-CT imaging system. This triple modality imager will actively support NIH-funded research addressing questions of fundamental importance in fields of experimental pharmacology, tumor biology, molecular imaging, and cognitive neuroscience. Massachusetts General Hospital has long a history of developing and conducting imaging research involving different isotope-based techniques, functional MRI, and optical imaging. Recently, the need for high-resolution imaging in small animal models has escalated, especially, the need for combined imaging modalities. Isotope-based imaging with PET and SPECT techniques enables functional imaging of the distribution of radio labeled ligands to measure physiological parameters such as blood flow, metabolism, receptor and/or enzyme function;however, these techniques do not necessarily delineate anatomical borders of tissues or organs, which severely limits interpretation of the data. Anatomical landmarks are extremely important, especially in whole-body imaging of the mouse. Anatomical imaging modalities like CT can provide these landmarks and, in addition, can provide accurate maps for attenuation correction of PET and SPECT data. The combined use of PET and SPECT can be extremely advantageous, for instance, for developing probes for cancer diagnosis and/or therapy. By using PET and SPECT imaging together, one probe can be radio labeled with two isotopes: one for PET and another for SPECT. The isotopes used for SPECT imaging generally have longer half-lives than PET isotopes, enabling long-term follow up studies not possible with PET imaging alone. The combined use of PET and SPECT imaging also enables imaging of metabolism (via PET) and blood flow (via SPECT) in the same imaging session. Currently we do not have instrumentation to allow us to acquire this information simultaneously. Our existing Concord micro PET system, P4, is a primate-size system;its resolution of 2 mm is not high enough to support imaging studies in mouse brain. We have used this PET system extensively for studies in the primate brain. We have also used it for imaging studies of xeno transplanted tumors in mouse models, but these studies are hindered by the inability to precisely localize tumor boundaries. A combined system for simultaneous acquisition of PET data with SPECT and CT data would allow us to realize the potential of such studies. Given the exceptional biomedical imaging research community at the MGH, the broad multimodality imaging resources of the Martinos Center, and the existing technical expertise and infrastructure in place, the proposed triple modality PET-CT-SPECT imager would immediately increase the efficiency, accessibility, and innovation of many existing research programs, and contribute to the MGH's strategy for an integrated biomedical imaging research environment. The proposed system manufactured by Siemens is the only triple modality system presently available.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR029495-01
Application #
7839808
Study Section
Special Emphasis Panel (ZRG1-SBIB-U (31))
Program Officer
Birken, Steven
Project Start
2010-07-08
Project End
2012-01-07
Budget Start
2010-07-08
Budget End
2012-01-07
Support Year
1
Fiscal Year
2010
Total Cost
$1,319,341
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Oliveira, Bruno L; Caravan, Peter (2017) Peptide-based fibrin-targeting probes for thrombus imaging. Dalton Trans 46:14488-14508
Hooker, Jacob M; Strebl, Martin G; Schroeder, Frederick A et al. (2017) Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine. Sci Rep 7:42136
Désogère, Pauline; Tapias, Luis F; Hariri, Lida P et al. (2017) Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models. Sci Transl Med 9:
Dos Santos Ferreira, Diego; Jesus de Oliveira Pinto, Bruno Luís; Kumar, Vidhya et al. (2017) Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice. Nanomedicine 13:1693-1701
Kil, Kun-Eek; Poutiainen, Pekka; Zhang, Zhaoda et al. (2016) Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4. Bioorg Med Chem Lett 26:133-9
Boros, Eszter; Holland, Jason P; Kenton, Nathaniel et al. (2016) Macrocycle-Based Hydroxamate Ligands for Complexation and Immunoconjugation of (89)Zirconium for Positron Emission Tomography (PET) Imaging. Chempluschem 81:274-281
Rotstein, Benjamin H; Placzek, Michael S; Krishnan, Hema S et al. (2016) Preclinical PET Neuroimaging of [11C]Bexarotene. Mol Imaging 15:
Strebl, Martin G; Wang, Changning; Schroeder, Frederick A et al. (2016) Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance. ACS Chem Neurosci 7:528-33
Ferreira, Diêgo Dos Santos; Faria, Samilla Dornelas; Lopes, Sávia Caldeira de Araújo et al. (2016) Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity, and biodistribution evaluation in a mouse model of bone metastasis. Int J Nanomedicine 11:3737-51
Blasi, Francesco; Oliveira, Bruno L; Rietz, Tyson A et al. (2015) Multisite Thrombus Imaging and Fibrin Content Estimation With a Single Whole-Body PET Scan in Rats. Arterioscler Thromb Vasc Biol 35:2114-21

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