: The objective of this application is the purchase of a BioScan NanoSPECT-CT scanner for in vivo small animal scanning. The requested purchase price is $1,063,916. Acquisition of the scanner will fulfill an unmet campus- wide need: high resolution small animal imaging in mice and rats injected with single photon emitting radiotracers. The scanner will permit a distinguished group of 13 NIH funded scientists to more optimally use animal models that have been created over years. A total of 21 NIH grants are supported in areas of neurobiology and neuro-oncology, cardiovascular biology and disease, arthritis, autoimmunity (lupus), oncology, and radiochemistry. Furthermore, we envisage a program in which the scanner will partially fulfill the educational imaging needs of the next generation molecular imagers and radiologists. The scanner was chosen after receiving quotes from the manufacturers. A team of 3 scientists, comprised of the PI (Radiologist- scientist), physicist, and a radiochemist, was formed to primarily evaluate the available commercial scanners. Site visits to installation sites, manufacturer's plants, or virtual demos were conducted for each of the major vendors. Scanner resolution, sensitivity, installed base, and ease of use were the dominant factors after considering the needs of the major users. The BioScan NanoSPECT-CT was considered the best choice for our users. Purchase of the scanner will lead to an immediate creation of 2 new jobs at UT Southwestern. Once investigators successfully use the scanner it is likely new funding will result that might lead to other jobs. The understanding that will result from application of SPECT/CT imaging of models of human disease may potentially lead to new therapies and improved healthcare for the American people.

Public Health Relevance

Small animal models of human diseases are important for advancing understanding of disease pathogenesis and disease treatment. Imaging studies in these animal models are critical for model validation, to follow disease progression, to monitor therapy efficacy, and minimize animal use. Purchasing the scanner will enhance research in these areas, potentially improve healthcare, and lead to creation of two jobs.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR029674-01
Application #
7843162
Study Section
Special Emphasis Panel (ZRG1-SBIB-L (30))
Program Officer
Birken, Steven
Project Start
2010-07-08
Project End
2011-07-07
Budget Start
2010-07-08
Budget End
2011-07-07
Support Year
1
Fiscal Year
2010
Total Cost
$894,058
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Gerber, David E; Hao, Guiyang; Watkins, Linda et al. (2015) Tumor-specific targeting by Bavituximab, a phosphatidylserine-targeting monoclonal antibody with vascular targeting and immune modulating properties, in lung cancer xenografts. Am J Nucl Med Mol Imaging 5:493-503
Hao, Guiyang; Liu, Wei; Hassan, Gedaa et al. (2015) A comparative study of trans- and cis-isomers of a bone-seeking agent, DO2A2P. Bioorg Med Chem Lett 25:571-4
Zhou, Chen; Hao, Guiyang; Thomas, Patrick et al. (2012) Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics. Angew Chem Int Ed Engl 51:10118-22