Morehouse School of Medicine?s overall strategic goal is to increase the critical mass of talented research faculty pursuing health disparities research;augment the pipeline of minority students/fellows pursuing research training in biomedical, clinical and behavioral sciences, and provide the infrastructure needed for investigators to achieve national recognition for their scientific discoveries and translation of new knowledge into community solutions and improved patient care for minorities. The goal of the 5-Year Endowment Strategic Plan is to support personalized prevention and intervention research through the translational continuum of basic science, clinical, and community-based research to move discoveries from the laboratory more rapidly into clinical applications and into widespread use in office settings and in the community. To this end, we will build capacity in Molecular Genetics Research, Clinical Research, and Community-based Prevention Research Infrastructure that will support the following objectives: I) Enhance the basic (and translational) research infrastructure for utilizing molecular (genomic, proteomic, and metabolomics) diagnostics and evidence-based, rationale design of therapies and technologies to reduce health disparities;II) Expand the critical mass of talented clinical investigators capable of accelerating translational science in the health disparity research focus areas related to: cancer, neuroscience/stroke, women?s health and cardio-metabolic disorders; III) Conduct community-based and public health informatics research to further define and understand the epidemiology of racial and ethnic health disparities and to develop innovative approaches to addressing cancer, neuroscience/stroke and cardiovascular disparities at the population level;and IV) Build a perpetual resource that will enable MSM to continually support growth and development in the areas of cancer, women?s health, neuroscience/stroke and cardiovascular disorders.
African Americans have the highest mortality rates from all major causes of death (cancer, diabetes, stroke, heart disease, AIDS). This project will seek to reduce these disparities by building research capacity for personalized clinical and community prevention strategies.
|Leng, Tiandong; Shi, Yejie; Xiong, Zhi-Gang et al. (2014) Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke? Prog Neurobiol 115:189-209|
|Tosini, Gianluca; Owino, Sharon; Guillaume, Jean-Luc et al. (2014) Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease. Bioessays 36:778-87|
|Hyacinth, Hyacinth I; Adams, Robert J; Voeks, Jenifer H et al. (2014) Frequent red cell transfusions reduced vascular endothelial activation and thrombogenicity in children with sickle cell anemia and high stroke risk. Am J Hematol 89:47-51|
|Li, Ming-Hua; Liu, Selina Qiuying; Inoue, Koichi et al. (2014) Acid-sensing ion channels in mouse olfactory bulb M/T neurons. J Gen Physiol 143:719-31|
|Meller, Camie L; Meller, Robert; Simons, Roger P et al. (2014) Patterns of ubiquitylation and SUMOylation associated with exposure to anoxia in embryos of the annual killifish Austrofundulus limnaeus. J Comp Physiol B 184:235-47|
|Davis, Sharon K; Gebreab, Samson; Quarells, Rakale et al. (2014) Social determinants of cardiovascular health among black and white women residing in Stroke Belt and Buckle regions of the South. Ethn Dis 24:133-43|
|Bian, Fang; Simon, Roger P; Li, Yun et al. (2014) Nascent proteomes in peripheral blood mononuclear cells as a novel source for biomarker discovery in human stroke. Stroke 45:1177-9|
|Jefferson, F; Ehlen, J C; Williams, N S et al. (2014) A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice. Endocrinology 155:4411-21|
|O'Bryant, Zaven; Vann, Kiara T; Xiong, Zhi-Gang (2014) Translational strategies for neuroprotection in ischemic stroke--focusing on acid-sensing ion channel 1a. Transl Stroke Res 5:59-68|
|Pulliam, John V K; Xu, Zhenfeng; Ford, Gregory D et al. (2013) Computational identification of conserved transcription factor binding sites upstream of genes induced in rat brain by transient focal ischemic stroke. Brain Res 1495:76-85|
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