Morehouse School of Medicine?s overall strategic goal is to increase the critical mass of talented research faculty pursuing health disparities research;augment the pipeline of minority students/fellows pursuing research training in biomedical, clinical and behavioral sciences, and provide the infrastructure needed for investigators to achieve national recognition for their scientific discoveries and translation of new knowledge into community solutions and improved patient care for minorities. The goal of the 5-Year Endowment Strategic Plan is to support personalized prevention and intervention research through the translational continuum of basic science, clinical, and community-based research to move discoveries from the laboratory more rapidly into clinical applications and into widespread use in office settings and in the community. To this end, we will build capacity in Molecular Genetics Research, Clinical Research, and Community-based Prevention Research Infrastructure that will support the following objectives: I) Enhance the basic (and translational) research infrastructure for utilizing molecular (genomic, proteomic, and metabolomics) diagnostics and evidence-based, rationale design of therapies and technologies to reduce health disparities;II) Expand the critical mass of talented clinical investigators capable of accelerating translational science in the health disparity research focus areas related to: cancer, neuroscience/stroke, women?s health and cardio-metabolic disorders; III) Conduct community-based and public health informatics research to further define and understand the epidemiology of racial and ethnic health disparities and to develop innovative approaches to addressing cancer, neuroscience/stroke and cardiovascular disparities at the population level;and IV) Build a perpetual resource that will enable MSM to continually support growth and development in the areas of cancer, women?s health, neuroscience/stroke and cardiovascular disorders.
African Americans have the highest mortality rates from all major causes of death (cancer, diabetes, stroke, heart disease, AIDS). This project will seek to reduce these disparities by building research capacity for personalized clinical and community prevention strategies.
|Hardy, Jimmaline J; Mooney, Scott R; Pearson, Andrea N et al. (2017) Assessing the accuracy of blood RNA profiles to identify patients with post-concussion syndrome: A pilot study in a military patient population. PLoS One 12:e0183113|
|Liu, Mingli; Inoue, Koichi; Leng, Tiandong et al. (2017) ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway. Oncotarget 8:8283-8293|
|Azzi, Abdelhalim; Evans, Jennifer A; Leise, Tanya et al. (2017) Network Dynamics Mediate Circadian Clock Plasticity. Neuron 93:441-450|
|Huang, Ming-Bo; Gonzalez, Ruben R; Lillard, James et al. (2017) Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells. Oncotarget 8:11302-11315|
|Hernandez-Encarnacion, Luisa; Sharma, Pankaj; Simon, Roger et al. (2017) Condition-specific transcriptional regulation of neuronal ion channel genes in brain ischemia. Int J Physiol Pathophysiol Pharmacol 9:192-201|
|Sánchez-Bretaño, Aída; Baba, Kenkichi; Janjua, Uzair et al. (2017) Melatonin partially protects 661W cells from H2O2-induced death by inhibiting Fas/FasL-caspase-3. Mol Vis 23:844-852|
|Laurent, Virgine; Sengupta, Anamika; Sánchez-Bretaño, Aída et al. (2017) Melatonin signaling affects the timing in the daily rhythm of phagocytic activity by the retinal pigment epithelium. Exp Eye Res 165:90-95|
|Leng, Tiandong; Lin, Suizhen; Xiong, Zhigang et al. (2017) Lidocaine suppresses glioma cell proliferation by inhibiting TRPM7 channels. Int J Physiol Pathophysiol Pharmacol 9:8-15|
|Cooper, Dexter L; Hernandez, Natalie D; Rollins, Latrice et al. (2017) HPV vaccine awareness and the association of trust in cancer information from physicians among males. Vaccine 35:2661-2667|
|Stewart, Tarianna; Koval, William T; Molina, Samuel A et al. (2017) Calibrated flux measurements reveal a nanostructure-stimulated transcytotic pathway. Exp Cell Res 355:153-161|
Showing the most recent 10 out of 281 publications