The long-range goal of activities at Meharry supported by NIMHD Endowment Program for Increasing Research and Resources Capacity is to develop a research capacity and infrastructure supportive of basic, translational, clinical and community-based research focused on eliminating health disparities. One of the acknowledged gaps in the nation's ability make significant inroads toward eliminated minority health disparities is the absence of a critical mass of clinician (physician and dental) scientists. Current trends in NIH funding suggest that scientists most likely to be recruited and retained in clinical research and subsequently obtain NIH funding are dual degree (M.D. /Ph.D. or D.D.S. /Ph.D.) recipients. Therefore the objective of the current application to endow highly integrated initiatives that will positively impact the above national priorities by 1) diversifying the future manpower in science; 2) increasing the number of physician- or dental-scientists;and 3) improving the written and oral communications skills of trainees (pre- and post-doctoral), particularly M.D./Ph.D. and D.D.S/Ph.D. students, and faculty investigators. It is widely known that communications skills in reading, writing and speaking clearly are crucial to scientific We plan to accomplish the goals of this application by pursuing the following two specific aims: 1. To expand and strengthen M.D./Ph.D. training and initiate a D.D.S./Ph.D. program at MMC;and 2. To develop an Office for Enhancing Scientific Communicating. This project will be a college-wide collaboration among the MMC School of Dentistry, the School of Graduate Studies and Research, the School of Medicine and the Office for Research. MMC is uniquely poised to execute this project given its long and successful history in training minority dentists, physicians and biomedical scientist MMC is a designated health professional School under the category of Certain Historically Black Colleges and Universities (HBCUs).

Public Health Relevance

This project will establish an innovative model for dual degree (M.D./Ph.D. and M.D./Ph.D.) training of underrepresented minorities. It is predicted that such individuals will make a significant contribution to translational and clinical research in the futue and positively impact the nationwide priority of eliminating health disparities.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Research and Institutional Resources Health Disparities Endowment Grants -Capacity Building (S21)
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Special Emphasis Panel (ZMD1-SRC (99))
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Stinson, Nathaniel
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Meharry Medical College
Schools of Medicine
United States
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Ho, Meng-Hsuan; Guo, Zhong-Mao; Chunga, Julio et al. (2016) Characterization of Innate Immune Responses of Human Endothelial Cells Induced by Porphyromonas gingivalis and Their Derived Outer Membrane Vesicles. Front Cell Infect Microbiol 6:139
Solberg, Lauren B; Freund Taylor, Carol (2015) Teaching Bioethics at Historically Black Colleges and Universities (HBCUs). J Health Care Poor Underserved 26:328-34
Goldzweig, Irwin A; Schlundt, David G; Moore, Wayne E et al. (2013) An academic, business, and community alliance to promote evidence-based public health policy: the case of primary seat belt legislation. J Health Care Poor Underserved 24:1364-77
Malloy, Melanie Theodore; McIntosh, Deneshia J; Walters, Treniqka S et al. (2013) Trafficking of the transcription factor Nrf2 to promyelocytic leukemia-nuclear bodies: implications for degradation of NRF2 in the nucleus. J Biol Chem 288:14569-83
Goldzweig, Irwin A; Levine, Robert S; Schlundt, David et al. (2013) Improving seat belt use among teen drivers: findings from a service-learning approach. Accid Anal Prev 59:71-5
Levine, Robert S; Williams, Jamila C; Kilbourne, Barbara A et al. (2012) Tuskegee redux: evolution of legal mandates for human experimentation. J Health Care Poor Underserved 23:104-25
Madison, M Nia; Kleshchenko, Yuliya Y; Nde, Pius N et al. (2007) Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction. Infect Immun 75:4780-91
Augustine, Swinburne A J; Kleshchenko, Yuliya Y; Nde, Pius N et al. (2006) Molecular cloning of a Trypanosoma cruzi cell surface casein kinase II substrate, Tc-1, involved in cellular infection. Infect Immun 74:3922-9
Nde, Pius N; Simmons, Kaneatra J; Kleshchenko, Yuliya Y et al. (2006) Silencing of the laminin gamma-1 gene blocks Trypanosoma cruzi infection. Infect Immun 74:1643-8