The purpose of the proposed project, entitled The Ohio State University Clinical and Translational Research Informatics Training Program (CTRIP), is to establish a novel and highly impactful Biomedical Informatics training initiative that focuses upon the emergent and rapidly growing sub-domains of Translational Bioinformatics (TBI) and Clinical Research Informatics (CRI). This program will leverage the unique scholarly and environmental strengths present at The Ohio State University Medical Center (OSUMC), and employ two well-established and highly successful pre- and post-doctoral training mechanisms present within The Ohio State University College of Medicine for degree granting purposes. Trainees will be involved in a combination of didactic and application-oriented instruction modalities, and will pursue independent research projects as a capstone to their curricula. The TBI track of the program will specifically focus upon pre-doctoral training, and combine core informatics competencies with a rigorous grounding in the biology of human disease. The CRI track of the program will specifically focus on post-doctoral training for individuals with terminal clinical degrees (e.g., MD, DO, or equivalent), and will similarly combine core informatics competencies with a rigorous grounding in clinical research methodology. The overall training program will house no more than six funded pre- and post-doctoral trainees at any given time. Our intent with the CTRIP program is to utilize an agile and highly innovative curricula development and evaluation plan, thus allowing for constant program optimization and adaptation to evolving trends and developments in the basic and applied Biomedical Informatics knowledge base.

Public Health Relevance

The Ohio State University Clinical and Translational Research Informatics Training Program (CTRIP) The purpose of the proposed project, entitled 'The Ohio State University Clinical and Translational Research Informatics Training Program (CTRIP)' is to establish a Biomedical Informatics training initiative that focuses upon the emergent and rapidly growing sub-domains of Translational Bioinformatics (TBI) and Clinical Research Informatics (CRI). This program will catalyze the formation and dissemination of an informatics workforce capable of advancing clinical and translational research in order to speed the process by which new basic science discoveries and translated into actionable therapies for human diseases.

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Continuing Education Training Grants (T15)
Project #
5T15LM011270-04
Application #
8875752
Study Section
Special Emphasis Panel (ZLM1-AP-T (01))
Program Officer
Florance, Valerie
Project Start
2012-07-01
Project End
2017-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
4
Fiscal Year
2015
Total Cost
$381,888
Indirect Cost
$23,896
Name
Ohio State University
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Latchana, Nicholas; Abrams, Zachary B; Howard, J Harrison et al. (2017) Plasma MicroRNA Levels Following Resection of Metastatic Melanoma. Bioinform Biol Insights 11:1177932217694837
Johnson, Travis S; Abrams, Zachary B; Mo, Xiaokui et al. (2017) Lack of human cytomegalovirus expression in single cells from glioblastoma tumors and cell lines. J Neurovirol 23:671-678
Guan, Xiangnan; LaPak, Kyle M; Hennessey, Rebecca C et al. (2017) Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth. Mol Cancer Res 15:237-249
Skinner, Cassandra C; McMichael, Elizabeth L; Jaime-Ramirez, Alena C et al. (2016) Folate-conjugated immunoglobulin targets melanoma tumor cells for NK cell effector functions. Melanoma Res 26:329-37
Moosavinasab, Soheil; Patterson, Jeremy; Strouse, Robert et al. (2016) 'RE:fine drugs': an interactive dashboard to access drug repurposing opportunities. Database (Oxford) 2016:
Latchana, Nicholas; Regan, Kelly; Howard, J Harrison et al. (2016) Global microRNA profiling for diagnostic appraisal of melanocytic Spitz tumors. J Surg Res 205:350-358
Regan, Kelly; Abrams, Zachary; Sharpnack, Michael et al. (2016) DISCOVERY OF MOLECULARLY TARGETED THERAPIES. Pac Symp Biocomput 21:1-8
Regan, Kelly; Moosavinasab, Soheil; Payne, Philip et al. (2016) Drug Repurposing Hypothesis Generation Using the ""RE:fine Drugs"" System. J Vis Exp :
Campbell, Amanda R; Regan, Kelly; Bhave, Neela et al. (2015) Gene expression profiling of the human natural killer cell response to Fc receptor activation: unique enhancement in the presence of interleukin-12. BMC Med Genomics 8:66
Alinari, Lapo; Mahasenan, Kiran V; Yan, Fengting et al. (2015) Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood 125:2530-43

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