This application is a competing renewal for an Institutional Ruth L. Kirschstein NRSA on the """"""""Genetic Aspects of Alcoholism."""""""" The objective of this training program is to provide high level predoctoral and postdoctoral research training on various aspects of the genetics of alcoholism. The main focus of the research training is on the genetic, biological and molecular basis of high alcohol drinking and seeking behavior. Major topics of research include neuronal mechanisms underlying high alcohol-drinking and -seeking behavior;the genetics (including microarrays and QTL) of alcohol metabolizing enzymes, and alcohol preference in selectively bred rodent lines;studies of factors that regulate the expression of genes relevant to alcoholism;analysis of the extent that genetically-influenced biobehavioral factors such as disinhibition-impulsivity and acute tolerance contribute to alcoholism risks in human populations;the use of the alcohol clamp method to assess the effects of genetics on electrophysiologic and subjective response to alcohol;effects of genetics and alcohol drinking on protein expression in selectively bred rodent lines;convergent functional genomic approach toward identifying candidate genes underlying alcoholism;neuropsycho-pharmacological and neuroimaging studies on alcohol craving in humans and rodents;comorbidity of alcohol addiction and schizophrenia in rodent models;and neurodevelopmental abnormalities of fetal alcohol syndrome in rodent models. The rationale for the research training program is that we do not understand how genetics influence alcohol drinking behavior;this is a very important topic and the field needs additional highly trained research investigators. In addition, our program offers translational research training, encompassing both human and animal studies. The program is designed to give the trainee exposure to and participation in high-powered research projects in which state-of-the-art methodologies are used. We expect to support 7 predoctoral trainees (after their first 2 years of study), and 3 postdoctoral trainees (with 0-1 year of experience). We anticipate supporting trainees for at least 3 years (some predoctoral trainees may take 1 or 2 additional years).

Public Health Relevance

There is convincing evidence that alcoholism runs in families. Identifying the genes that contribute to alcoholism, and understanding how these genes influence neuronal functions would greatly contribute toward understanding and treating alcoholism.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA007462-25
Application #
7845623
Study Section
Special Emphasis Panel (ZAA1-HH (50))
Program Officer
Egli, Mark
Project Start
1985-09-27
Project End
2011-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
25
Fiscal Year
2010
Total Cost
$433,959
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Psychiatry
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Melón, Laverne C; Nolan, Zachary T; Colar, Delphine et al. (2017) Activation of extrasynaptic ?-GABAA receptors globally or within the posterior-VTA has estrous-dependent effects on consumption of alcohol and estrous-independent effects on locomotion. Horm Behav 95:65-75
Finn, Peter R; Gerst, Kyle; Lake, Allison et al. (2017) Decisions to Attend and Drink at Party Events: The Effects of Incentives and Disincentives and Lifetime Alcohol and Antisocial Problems. Alcohol Clin Exp Res 41:1622-1629
Gerst, Kyle R; Gunn, Rachel L; Finn, Peter R (2017) Delay Discounting of Losses in Alcohol Use Disorders and Antisocial Psychopathology: Effects of a Working Memory Load. Alcohol Clin Exp Res 41:1768-1774
Öztürk, Nail Can; Resendiz, Marisol; Öztürk, Hakan et al. (2017) DNA Methylation program in normal and alcohol-induced thinning cortex. Alcohol 60:135-147
Kasten, C R; Zhang, Y; Boehm 2nd, S L (2017) Acute and long-term effects of ?9-tetrahydrocannabinol on object recognition and anxiety-like activity are age- and strain-dependent in mice. Pharmacol Biochem Behav 163:9-19
Beckwith, Steven Wesley; Czachowski, Cristine Lynn (2016) Alcohol-Preferring P Rats Exhibit Elevated Motor Impulsivity Concomitant with Operant Responding and Self-Administration of Alcohol. Alcohol Clin Exp Res 40:1100-10
Hauser, Sheketha R; Deehan Jr, Gerald A; Knight, Christopher P et al. (2016) Parameters of Context-Induced Ethanol (EtOH)-Seeking in Alcohol-Preferring (P) Rats: Temporal Analysis, Effects of Repeated Deprivation, and EtOH Priming Injections. Alcohol Clin Exp Res 40:2229-2239
Hershberger, Alexandra R; VanderVeen, J Davis; Karyadi, Kenny A et al. (2016) Transitioning From Cigarettes to Electronic Cigarettes Increases Alcohol Consumption. Subst Use Misuse 51:1838-45
Kasten, C R; Frazee, A M; Boehm 2nd, S L (2016) Developing a model of limited-access nicotine consumption in C57Bl/6J mice. Pharmacol Biochem Behav 148:28-37
Deehan Jr, Gerald A; Knight, Christopher P; Waeiss, R Aaron et al. (2016) Peripheral Administration of Ethanol Results in a Correlated Increase in Dopamine and Serotonin Within the Posterior Ventral Tegmental Area. Alcohol Alcohol 51:535-40

Showing the most recent 10 out of 226 publications