This application requests continued support for a Postdoctoral Training Program, now in its 30th year, designed to produce well-trained independent researchers in the area of alcohol abuse and alcoholism. Funds are requested to support 8 fellows per year (levels 0-2), with the average duration of support being two years. This multidisciplinary program has three broad areas of training: pharmacology, genetics, and behavior. These areas are covered by 28 well-funded training faculty preceptors, who focus both on basic and clinical alcohol/drug abuse research. The majority of the faculty currently on the grant will continue to participate. A number of units within the Denver and Boulder campuses of the University of Colorado are involved: the Departments of Pharmacology, Psychiatry, Pharmaceutical Sciences, Psychology, Integrative Physiology, and Medicine/Division of Clinical Pharmacology and Toxicology;the Institute for Behavioral Genetics;the Colorado component of the NIAAA-funded Integrated Neuroscience Initiative on Alcoholism (INIA);and the NIDA-funded Center for the Genetics of Antisocial Drug Dependence. Trainees with doctoral degrees are recruited from a broad range of disciplines. Concerted efforts have been made to recruit trainees from underrepresented racial/ethnic groups and to contribute to longer-term programs to """"""""fill the pipeline."""""""" Trainees work primarily in one lab, but collaborative interactions with other preceptors and trainees are strongly encouraged. All of the preceptors use state-of-the-art pharmacological, genetic, genomic and/or behavioral approaches. Training in quantitative and molecular genetics, combined with a broad range of pharmacological approaches, allows the fellows to dissect the molecular, cellular, and genetic bases for behavioral reactions to drugs and the environment and susceptibility to alcohol addiction. Another important characteristic of this Training Program is the opportunity for trainees to participate in interactions between basic science and clinical practice. Contact with other faculty and trainees through a regular seminar series and various courses, including Ethics in Research, complete the training environment. Trianees are also encouraged to write individual NRSAs and present their work in local seminars, as well as at national and international meetings. Past trainees from this program have been very successful, and a number are continuing to make significant contributions in the alcohol and drug abuse fields.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA007464-35
Application #
8101002
Study Section
Special Emphasis Panel (ZAA1-HH (81))
Program Officer
Reilly, Matthew
Project Start
1987-01-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
35
Fiscal Year
2011
Total Cost
$309,515
Indirect Cost
Name
University of Colorado Denver
Department
Pharmacology
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Sinnen, Brooke L; Bowen, Aaron B; Forte, Jeffrey S et al. (2017) Optogenetic Control of Synaptic Composition and Function. Neuron 93:646-660.e5
Lind, Kimberly E; Gutierrez, Eric J; Yamamoto, Dorothy J et al. (2017) Sex disparities in substance abuse research: Evaluating 23 years of structural neuroimaging studies. Drug Alcohol Depend 173:92-98
Tencer, Adam H; Cox, Khan L; Di, Luo et al. (2017) Covalent Modifications of Histone H3K9 Promote Binding of CHD3. Cell Rep 21:455-466
Tencer, Adam H; Gatchalian, Jovylyn; Klein, Brianna J et al. (2017) A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO. Structure 25:1530-1539.e3
Wills, Amanda G; Evans, Luke M; Hopfer, Christian (2017) Phenotypic and Genetic Relationship Between BMI and Drinking in a Sample of UK Adults. Behav Genet 47:290-297
Andrews, Forest H; Strahl, Brian D; Kutateladze, Tatiana G (2016) Insights into newly discovered marks and readers of epigenetic information. Nat Chem Biol 12:662-8
Klein, Brianna J; Muthurajan, Uma M; Lalonde, Marie-Eve et al. (2016) Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation. Nucleic Acids Res 44:472-84
Andrews, Forest H; Tong, Qiong; Sullivan, Kelly D et al. (2016) Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase. Cell Rep 16:3195-3207
Andrews, Forest H; Shinsky, Stephen A; Shanle, Erin K et al. (2016) The Taf14 YEATS domain is a reader of histone crotonylation. Nat Chem Biol 12:396-8
Andrews, Forest H; Shanle, Erin K; Strahl, Brian D et al. (2016) The essential role of acetyllysine binding by the YEATS domain in transcriptional regulation. Transcription 7:14-20

Showing the most recent 10 out of 129 publications