This is a proposal for the continuation of a training grant, the primary purpose of which is to provide stipends for five predoctoral and three postdoctoral fellows who will be broadly and intensively trained to conduct research on the neurochemical and behavioral effects of ethanol. The training program will promote and support collaborative research. Neurochemical research training programs will include ethanol's effects on 1) electrophysiology and neurochemistry of sodium, calcium and other ion channels (Bittner, Leslie), 2) signaling mechanisms with emphasis on phosphorylation, cyclic AMP, cyclic GMP and polyphosphoinositide systems (Gonzales, Leslie), 3) release and turnover of acetylcholine, dopamine, norepinephrine and other neurotransmitters (Leslie, Wilcox, Erickson, and Abell), 4) neurotransmitter receptor interactions (Leslie, Randall, Wilcox) and neurotransmitter degrading enzymes (Wilcox, Abell), 5) neurochemistry associated with aging (Randall, Wilcox, Schallert, Erickson, Abell, and Leslie), and 6) receptors and neuronal enzymes and proteins using molecular biology techniques (Abell, Leslie, Wilcox, and Wong). Research on the behavioral effects of ethanol will include its influence on motor skills and reaction times in young and old animals (Schallert and Wilcox) and recovery of function subsequent to brain lesioning in young and old animals (Schallert, Leslie, Wilcox). We are also fortunate to have expertise to train students in psychosocial aspects of alcohol research (Kim Fromme). Postdoctoral fellows will choose an area of interest at the onset of their training. Predoctoral graduate training will begin with a required rotation through the laboratory of each faculty member prior to choosing an advisor for dissertation research. Predoctoral students will be required to complete a series of core course requirements covering ethanol's actions on the central nervous system. In addition, students will be required to complete required coursework in the areas of scientific ethics, experimental design and statistical analysis. A key aspect of our training efforts has been our focus on minority recruitment and training. We feel that we been quite successful in this area and will continue to have minority recruitment and training as a primary focus during the next award period. The training faculty included in this application have an excellent history of collaboration and sharing of laboratory space and equipment. The research laboratories are well equipped with the latest instrumentation for neurochemical and behavioral testing.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA007471-14
Application #
6136983
Study Section
Special Emphasis Panel (ZAA1-DD (02))
Project Start
1987-09-30
Project End
2002-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
14
Fiscal Year
2000
Total Cost
$220,450
Indirect Cost
Name
University of Texas Austin
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78712
Wilhite, Emily R; Mallard, Travis; Fromme, Kim (2018) A longitudinal event-level investigation of alcohol intoxication, alcohol-related blackouts, childhood sexual abuse, and sexual victimization among college students. Psychol Addict Behav 32:289-300
Robison, Christopher L; Martz, Julia R; Dominguez, Juan M (2018) Influence of preoptic estradiol on behavioral and neural response to cocaine in female Sprague-Dawley rats. Psychopharmacology (Berl) 235:663-672
Mallard, Travis T; Ashenhurst, James R; Harden, K Paige et al. (2018) GABRA2, alcohol, and illicit drug use: An event-level model of genetic risk for polysubstance use. J Abnorm Psychol 127:190-201
Renteria, Rafael; Buske, Tavanna R; Morrisett, Richard A (2018) Long-term subregion-specific encoding of enhanced ethanol intake by D1DR medium spiny neurons of the nucleus accumbens. Addict Biol 23:689-698
Cofresí, Roberto U; Lee, Hongjoo J; Monfils, Marie-H et al. (2018) Characterizing conditioned reactivity to sequential alcohol-predictive cues in well-trained rats. Alcohol 69:41-49
Mittal, Nitish; Thakore, Neha; Reno, James M et al. (2018) Alcohol-naïve USVs distinguish male HAD-1 from LAD-1 rat strains. Alcohol 68:9-17
Ashenhurst, James R; Wilhite, Emily R; Harden, K Paige et al. (2017) Number of Sexual Partners and Relationship Status Are Associated With Unprotected Sex Across Emerging Adulthood. Arch Sex Behav 46:419-432
Renteria, Rafael; Maier, Esther Y; Buske, Tavanna R et al. (2017) Selective alterations of NMDAR function and plasticity in D1 and D2 medium spiny neurons in the nucleus accumbens shell following chronic intermittent ethanol exposure. Neuropharmacology 112:164-171
Wilhite, Emily R; Fromme, Kim (2017) The Differential Influence of Drinking, Sensation Seeking, and Impulsivity on the Perpetration of Unwanted Sexual Advances and Sexual Coercion. J Interpers Violence :886260517742151
Cofresí, Roberto U; Lewis, Suzanne M; Chaudhri, Nadia et al. (2017) Postretrieval Extinction Attenuates Alcohol Cue Reactivity in Rats. Alcohol Clin Exp Res 41:608-617

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