This is a proposal for the continuation of a training grant to support six predoctoral and three postdoctoral fellows who will be broadly and intensively trained to conduct research on alcoholism. Training areas span the breadth of state-of-the-art approaches including molecular biology and genetics, electrophysiology, cellular imaging, neurochemistry, and behavior. Research models include both animal and human. The training program will promote and support collaborative research. Molecular biology training will encompass studies of the function of ligand-gated ion channels in cellular expression systems (Mihic, Harris), development of new transgenic animal models (Harris, Mihic), and identification of ethanol responsive genes (Iyer, Bergeson, Harris, Mihic). Genetics training will involve genotyping of human and animal subjects (Fromme, Harris, Bergeson, lyer). Electrophysiological and microscopic imaging training will comprise experiments with whole cell and intracellular methods in single cells and in brain slices (Morrisett, Mihic, Harris). Training in neurochemistry will focus on intracellular and extracellular signaling mechanisms with an emphasis on phosphorylation (Morrisett, Leslie), release and transport of glutamate, dopamine, and other neurotransmitters (Gonzales, Harris), and expression of synaptic proteins (Leslie, Morrisett). Research training in the behavioral effects of ethanol (motor skills, reinforcement, anxiety, and withdrawal) will be done (,Duvauchelle, Harris, Gonzales, Bergeson). Training in psychosocial aspects of alcohol research (Fromme) and the interaction of genotype and alcohol drinking in humans (Fromme, Bergeson, Harris, lyer) will also be done. The training program will continue to emphasize professional development (improvement of oral and written communication skills) (Erickson). Postdoctoral fellows will choose a project at the onset of their training. Predoctoral trainees will rotate through the laboratories of selected faculty members prior to choosing an advisor for dissertation research. Predoctoral students will be required to complete a series of core course requirements covering ethanol's actions on the central nervous system, scientific ethics, experimental design, and statistical analysis. We will continue to focus on minority recruitment. The training program has an excellent record and will continue to focus on producing well qualified alcohol researchers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA007471-19
Application #
6917129
Study Section
Special Emphasis Panel (ZAA1-DD (01))
Program Officer
Grandison, Lindsey
Project Start
1987-09-30
Project End
2007-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
19
Fiscal Year
2005
Total Cost
$249,506
Indirect Cost
Name
University of Texas Austin
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
170230239
City
Austin
State
TX
Country
United States
Zip Code
78712
Renteria, Rafael; Buske, Tavanna R; Morrisett, Richard A (2018) Long-term subregion-specific encoding of enhanced ethanol intake by D1DR medium spiny neurons of the nucleus accumbens. Addict Biol 23:689-698
Cofresí, Roberto U; Lee, Hongjoo J; Monfils, Marie-H et al. (2018) Characterizing conditioned reactivity to sequential alcohol-predictive cues in well-trained rats. Alcohol 69:41-49
Mittal, Nitish; Thakore, Neha; Reno, James M et al. (2018) Alcohol-naïve USVs distinguish male HAD-1 from LAD-1 rat strains. Alcohol 68:9-17
Wilhite, Emily R; Mallard, Travis; Fromme, Kim (2018) A longitudinal event-level investigation of alcohol intoxication, alcohol-related blackouts, childhood sexual abuse, and sexual victimization among college students. Psychol Addict Behav 32:289-300
Robison, Christopher L; Martz, Julia R; Dominguez, Juan M (2018) Influence of preoptic estradiol on behavioral and neural response to cocaine in female Sprague-Dawley rats. Psychopharmacology (Berl) 235:663-672
Mallard, Travis T; Ashenhurst, James R; Harden, K Paige et al. (2018) GABRA2, alcohol, and illicit drug use: An event-level model of genetic risk for polysubstance use. J Abnorm Psychol 127:190-201
Ashenhurst, James R; Harden, K Paige; Mallard, Travis T et al. (2017) Developmentally Specific Associations Between CNR1 Genotype and Cannabis Use Across Emerging Adulthood. J Stud Alcohol Drugs 78:686-695
Wilhite, Emily R; Ashenhurst, James R; Marino, Elise N et al. (2017) Freshman year alcohol and marijuana use prospectively predict time to college graduation and subsequent adult roles and independence. J Am Coll Health 65:413-422
Reno, James M; Thakore, Neha; Cormack, Lawrence K et al. (2017) Negative Affect-Associated USV Acoustic Characteristics Predict Future Excessive Alcohol Drinking and Alcohol Avoidance in Male P and NP Rats. Alcohol Clin Exp Res 41:786-797
Ashenhurst, James R; Wilhite, Emily R; Harden, K Paige et al. (2017) Number of Sexual Partners and Relationship Status Are Associated With Unprotected Sex Across Emerging Adulthood. Arch Sex Behav 46:419-432

Showing the most recent 10 out of 157 publications