This is a proposal for the renewal of a training grant, the primary purpose of which is to provide stipends for seven predoctoral and two postdoctoral fellows who will be broadly and intensively trained to conduct research on alcoholism. This program has a long history of training predoctoral and postdoctoral students in alcoholism research to help the national effort of producing the next generation of independent scientists with a focus on alcohol research. Training opportunities span the breadth of state-of-the-art approaches including molecular biology and genetics, electrophysiology, cellular imaging, neurochemistry, and behavior. Research models include both animal and human. The training program will promote and support collaborative research across multiple departmental units and Ph.D. programs including Clinical Psychology, Behavioral Neuroscience, Pharmacology, Neuroscience, and Cellular and Molecular Biology. Molecular biology training will encompass 1) studies of the function of excitatory and inhibitory ion channels in cellular expression systems (Mihic, Harris), and 2) development of new transgenic animal models (Harris, Mihic, Pierce-Shimomura, Atkinson), and 3) identification of ethanol responsive genes (Atkinson, Harris, Mihic, Pierce-Shimomura). Genetics training will involve genotyping of human and animal subjects (Fromme, Harris, Mayfield). Electrophysiological and microscopic imaging training will comprise experiments with whole cell and intracellular methods in single cells and in brain slices (Morrisett, Mihic, Harris, Atkinson, Pierce-Shimomura). Training in neurochemistry will focus on 1) intracellular and extracellular signaling mechanisms with an emphasis on phosphorylation (Morrisett, Mayfield), 2) release and transport of glutamate, dopamine, and other neurotransmitters (Gonzales, Harris), and 3) expression of proteins (Harris, Mayfield, Morrisett). Research on the behavioral effects of ethanol will include its influence on motor skills, reinforcement, anxiety, and withdrawal (Harris, Gonzales). Training in psychosocial aspects of alcohol research (Fromme) and the interaction of genotype and effects of alcohol drinking in humans (Fromme, Harris) will also be done. The training program will continue to emphasize professional development including improvement of oral and written communication skills. Predoctoral students will be required to complete a series of core course requirements, scientific ethics, experimental design, and statistical analysis, and grant writing, and will end up with a Ph.D. degree. Postdoctoral training will be for three years and consist of focused alcohol research guided by a faculty mentor. We will continue to focus on minority recruitment. The training faculty has an excellent history of collaboration with a primary focus on alcohol research. The research laboratories are well equipped with the latest instrumentation for neurochemical and behavioral testing.

Public Health Relevance

This training program has direct relevance to public health, primarily in the area of alcoholism, a devastating disease in the United States and worldwide. Trainees will learn cutting edge research techniques and will perform research on alcohol related problems to provide new information that may guide treatments or further our understanding of the causes and consequences of the disease of alcoholism.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
3T32AA007471-28S1
Application #
8836316
Study Section
Special Emphasis Panel (ZAA1 (01))
Program Officer
Regunathan, Soundar
Project Start
1987-09-30
Project End
2017-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
28
Fiscal Year
2014
Total Cost
$56,732
Indirect Cost
$4,202
Name
University of Texas Austin
Department
Administration
Type
Schools of Pharmacy
DUNS #
170230239
City
Austin
State
TX
Country
United States
Zip Code
78712
Wilhite, Emily R; Mallard, Travis; Fromme, Kim (2018) A longitudinal event-level investigation of alcohol intoxication, alcohol-related blackouts, childhood sexual abuse, and sexual victimization among college students. Psychol Addict Behav 32:289-300
Robison, Christopher L; Martz, Julia R; Dominguez, Juan M (2018) Influence of preoptic estradiol on behavioral and neural response to cocaine in female Sprague-Dawley rats. Psychopharmacology (Berl) 235:663-672
Mallard, Travis T; Ashenhurst, James R; Harden, K Paige et al. (2018) GABRA2, alcohol, and illicit drug use: An event-level model of genetic risk for polysubstance use. J Abnorm Psychol 127:190-201
Renteria, Rafael; Buske, Tavanna R; Morrisett, Richard A (2018) Long-term subregion-specific encoding of enhanced ethanol intake by D1DR medium spiny neurons of the nucleus accumbens. Addict Biol 23:689-698
Cofresí, Roberto U; Lee, Hongjoo J; Monfils, Marie-H et al. (2018) Characterizing conditioned reactivity to sequential alcohol-predictive cues in well-trained rats. Alcohol 69:41-49
Mittal, Nitish; Thakore, Neha; Reno, James M et al. (2018) Alcohol-naïve USVs distinguish male HAD-1 from LAD-1 rat strains. Alcohol 68:9-17
Ashenhurst, James R; Harden, K Paige; Mallard, Travis T et al. (2017) Developmentally Specific Associations Between CNR1 Genotype and Cannabis Use Across Emerging Adulthood. J Stud Alcohol Drugs 78:686-695
Wilhite, Emily R; Ashenhurst, James R; Marino, Elise N et al. (2017) Freshman year alcohol and marijuana use prospectively predict time to college graduation and subsequent adult roles and independence. J Am Coll Health 65:413-422
Reno, James M; Thakore, Neha; Cormack, Lawrence K et al. (2017) Negative Affect-Associated USV Acoustic Characteristics Predict Future Excessive Alcohol Drinking and Alcohol Avoidance in Male P and NP Rats. Alcohol Clin Exp Res 41:786-797
Ashenhurst, James R; Wilhite, Emily R; Harden, K Paige et al. (2017) Number of Sexual Partners and Relationship Status Are Associated With Unprotected Sex Across Emerging Adulthood. Arch Sex Behav 46:419-432

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