The Biomedical Alcohol Research Training Program will prepare pre- and post-doctoral PhD, or combined MD/PhD candidates, and postdoctoral fellows with MD, DVM and/or PhD degrees for research careers focused on the biomedical consequences of alcohol consumption and abuse. Through joint efforts, Core and Support Faculty from the Louisiana State University Health Sciences Center Schools of Medicine and Public Health, and Tulane School of Public Health, and National Primate Research Center will participate in interdisciplinary training and mentoring on diverse areas of alcohol research, and specialty training including experimental design and statistical analysis, use of animals in research, and translational approaches. Trainees will pursue alcohol research projects under four interrelated themes 1) Alcohol/HIV Disease;2) Alcohol/ Neuro-immune-modulation;3) Alcohol/Stem Cell and Progenitor Cell Biology;and 4) Alcohol/ Neurobehavioral interactions. The Training Program is designed to develop trainee's technical, analytical, and communication skills that will allow them to advance knowledge by conducting hypotheses-driven mechanistic research on the biomedical consequences of alcohol consumption and abuse. Using rodent, non-human primate models, as well as clinical and translational approaches;trainees will have a broad range of scientific areas to provide opportunities for research training. Didactic and educational programs including the study of responsible conduct of research will integrate pre- and post-doctoral trainee development. Participation in a professional development program that is designed to increase their knowledge base in the alcohol research field, understanding of experimental design and analysis, grantsmanship, institutional requirement to conduct research as well as their written and oral communication skills will further enrich their training experienc. Five pre-doctoral trainees in the PhD, or MD, PhD combined program, and 4 postdoctoral fellows (MD, DVM and/or PhD) will be in the Program each year. Particular emphasis will be placed in recruitment of outstanding candidates for the combined MD, PhD program. Furthermore, efforts to continue our recruitment, mentoring, and retention of fellows from diverse cultural, ethnic, and training background, particularly those that are under-represented in the biomedical research field will be emphasized. The goal of the program is to provide mentorship and focused training so that emerging MD and PhD scientists can become familiar with the biomedical problems related to alcohol consumption and acquire the tools to do high quality, competitive research.

Public Health Relevance

This training grant will address the health needs of our nation by training the future generation of basic and translational scientists to address the major health concern of biomedical consequences of alcohol use disorders (AUD). Yearly in the United States alone AUD cause premature death in about 120,000 people, adversely affects the lives of approximately 14 million Americans and their family members at a health care cost to society of greater than $200 billion dollars. This training program is relevant to healthcare, because our nation is facing a critical shortage of US citizens entering the biomedical research field.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Wang, Joe
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Louisiana State Univ Hsc New Orleans
Schools of Medicine
New Orleans
United States
Zip Code
Katz, Paige S; Sulzer, Jesse K; Impastato, Renata A et al. (2015) Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury. J Neurotrauma 32:297-306
Teng, Sophie X; Katz, Paige S; Maxi, John K et al. (2015) Alcohol exposure after mild focal traumatic brain injury impairs neurological recovery and exacerbates localized neuroinflammation. Brain Behav Immun 45:145-56
Molina, Patricia E; Bagby, Gregory J; Nelson, Steve (2014) Biomedical consequences of alcohol use disorders in the HIV-infected host. Curr HIV Res 12:265-75
Doggett, Travis M; Breslin, Jerome W (2014) Acute alcohol intoxication-induced microvascular leakage. Alcohol Clin Exp Res 38:2414-26
Molina, Patricia E; Gardner, Jason D; Souza-Smith, Flavia M et al. (2014) Alcohol abuse: critical pathophysiological processes and contribution to disease burden. Physiology (Bethesda) 29:203-15
Roltsch, Emily A; Baynes, Brittni B; Mayeux, Jacques P et al. (2014) Predator odor stress alters corticotropin-releasing factor-1 receptor (CRF1R)-dependent behaviors in rats. Neuropharmacology 79:83-9
Choi, Sun-Mi; McAleer, Jeremy P; Trevejo-Nunez, Giraldina et al. (2014) Acute alcohol intoxication impairs methicillin-resistant Staphylococcus aureus clearance in the lung by impeding epithelial production of Reg3?. Infect Immun 82:1402-7
Whitaker, Annie M; Gilpin, Nicholas W; Edwards, Scott (2014) Animal models of post-traumatic stress disorder and recent neurobiological insights. Behav Pharmacol 25:398-409
Dodd, Tracy; Simon, Liz; LeCapitaine, Nicole J et al. (2014) Chronic binge alcohol administration accentuates expression of pro-fibrotic and inflammatory genes in the skeletal muscle of simian immunodeficiency virus-infected macaques. Alcohol Clin Exp Res 38:2697-706
Loganantharaj, Nisha; Nichols, Whitney A; Bagby, Gregory J et al. (2014) The effects of chronic binge alcohol on the genital microenvironment of simian immunodeficiency virus-infected female rhesus macaques. AIDS Res Hum Retroviruses 30:783-91

Showing the most recent 10 out of 48 publications