This competing continuation application requests support for 6 postdoctoral fellows for primary training in aspects of alcohol research related to 4 major tracks: (i) genetic epidemiology;(ii) gene discovery, (iii) developmental psychopathology and longitudinal studies, and (iv) cognitive neuroscience (principally involving electrophysiology studies). In addition to specialization in a primary discipline, trainees will be encouraged to obtain a sufficient familiarity with other focus areas to facilitate fruitful cross-disciplinary collaborations in their research careers. The training program will ordinarily be of 3 years duration, reflecting the diverse backgrounds of our applicant pool (e.g. clinical psychology, social work, psychiatry, mathematics, other behavioral science). The training program emphasizes a research apprenticeship model, combining research under the mentorship of one or more experienced research mentors with more formal training through didactic courses and seminar programs;
and aims to help trainees make progress on their pathway to independence through high-impact first author publications, refinement of research ideas that will support a first grant submission as PI, and assistance in collection of feasibility data to support a first submission. Six of 10 who have completed fellowships have successful NIH applications as PI;2 have applications in process;and 2 trained in an area (basic neuroscience) dropped in this competing application. Major strengths of the program are its affiliation with a flourishing Alcoholism Research Center, the availability of senior faculty with an extensive program of alcoholism research, representing expertise in many aspects of statistical, molecular and genetic epidemiologic research on alcoholism;the highly productive research environment;the availability of major genetic data-bases offering many opportunities for innovative analyses and high-impact publications;access to ongoing projects that offer many opportunities for trainees to obtain expertise in clinical research;the program's location in one of the nation's leading medical schools, allowing trainees to take advantage of a rich array of didactic courses and seminars and research experiences;and the long tradition of successful mentoring and research training of scientists and clinician scientists from diverse intellectual backgrounds.

Public Health Relevance

Parent-to-child transmission of alcoholism often is characterized by genetic inheritance occurring in the context of high-risk environmental exposures associated with parental alcoholism. Trainees will learn to study this process through genetic including gene discovery-, longitudinal, and cognitive neuroscience approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA007580-13
Application #
8296344
Study Section
Special Emphasis Panel (ZAA1-HH (32))
Program Officer
Parsian, Abbas
Project Start
2000-07-01
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
13
Fiscal Year
2012
Total Cost
$175,414
Indirect Cost
$19,068
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
van den Berg, Stéphanie M; de Moor, Marleen H M; Verweij, Karin J H et al. (2016) Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behav Genet 46:170-82
Munn-Chernoff, Melissa A; Baker, Jessica H (2016) A Primer on the Genetics of Comorbid Eating Disorders and Substance Use Disorders. Eur Eat Disord Rev 24:91-100
Diemer, Elizabeth W; Grant, Julia D; Munn-Chernoff, Melissa A et al. (2015) Gender Identity, Sexual Orientation, and Eating-Related Pathology in a National Sample of College Students. J Adolesc Health 57:144-9
Munn-Chernoff, Melissa A; Grant, Julia D; Bucholz, Kathleen K et al. (2015) Bulimic Behaviors and Early Substance Use: Findings from a Cotwin-Control Study. Alcohol Clin Exp Res 39:1740-8
Munn-Chernoff, Melissa A; Keel, Pamela K; Klump, Kelly L et al. (2015) Prevalence of and familial influences on purging disorder in a community sample of female twins. Int J Eat Disord 48:601-6
Munn-Chernoff, Melissa A; Grant, Julia D; Agrawal, Arpana et al. (2015) Are there common familial influences for major depressive disorder and an overeating-binge eating dimension in both European American and African American female twins? Int J Eat Disord 48:375-82
Genetics of Personality Consortium; de Moor, Marleen H M; van den Berg, Stéphanie M et al. (2015) Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. JAMA Psychiatry 72:642-50
Duncan, Alexis E; Sartor, Carolyn E; Jonson-Reid, Melissa et al. (2015) Associations between body mass index, post-traumatic stress disorder, and child maltreatment in young women. Child Abuse Negl 45:154-62
Blustein, Erica C; Munn-Chernoff, Melissa A; Grant, Julia D et al. (2015) The Association of Low Parental Monitoring With Early Substance Use in European American and African American Adolescent Girls. J Stud Alcohol Drugs 76:852-61
Munn-Chernoff, Melissa A; Grant, Julia D; Agrawal, Arpana et al. (2015) Genetic overlap between alcohol use disorder and bulimic behaviors in European American and African American women. Drug Alcohol Depend 153:335-40

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