This competing continuation application requests support for 6 postdoctoral fellows for primary training in aspects of alcohol research related to 4 major tracks: (i) genetic epidemiology;(ii) gene discovery, (iii) developmental psychopathology and longitudinal studies, and (iv) cognitive neuroscience (principally involving electrophysiology studies). In addition to specialization in a primary discipline, trainees will be encouraged to obtain a sufficient familiarity with other focus areas to facilitate fruitful cross-disciplinary collaborations in their research careers. The training program will ordinarily be of 3 years duration, reflecting the diverse backgrounds of our applicant pool (e.g. clinical psychology, social work, psychiatry, mathematics, other behavioral science). The training program emphasizes a research apprenticeship model, combining research under the mentorship of one or more experienced research mentors with more formal training through didactic courses and seminar programs;
and aims to help trainees make progress on their pathway to independence through high-impact first author publications, refinement of research ideas that will support a first grant submission as PI, and assistance in collection of feasibility data to support a first submission. Six of 10 who have completed fellowships have successful NIH applications as PI;2 have applications in process;and 2 trained in an area (basic neuroscience) dropped in this competing application. Major strengths of the program are its affiliation with a flourishing Alcoholism Research Center, the availability of senior faculty with an extensive program of alcoholism research, representing expertise in many aspects of statistical, molecular and genetic epidemiologic research on alcoholism;the highly productive research environment;the availability of major genetic data-bases offering many opportunities for innovative analyses and high-impact publications;access to ongoing projects that offer many opportunities for trainees to obtain expertise in clinical research;the program's location in one of the nation's leading medical schools, allowing trainees to take advantage of a rich array of didactic courses and seminars and research experiences;and the long tradition of successful mentoring and research training of scientists and clinician scientists from diverse intellectual backgrounds.

Public Health Relevance

Parent-to-child transmission of alcoholism often is characterized by genetic inheritance occurring in the context of high-risk environmental exposures associated with parental alcoholism. Trainees will learn to study this process through genetic including gene discovery-, longitudinal, and cognitive neuroscience approaches.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA007580-15
Application #
8685847
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Parsian, Abbas
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
van den Berg, Stéphanie M; de Moor, Marleen H M; Verweij, Karin J H et al. (2016) Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behav Genet 46:170-82
Munn-Chernoff, Melissa A; Baker, Jessica H (2016) A Primer on the Genetics of Comorbid Eating Disorders and Substance Use Disorders. Eur Eat Disord Rev 24:91-100
Diemer, Elizabeth W; Grant, Julia D; Munn-Chernoff, Melissa A et al. (2015) Gender Identity, Sexual Orientation, and Eating-Related Pathology in a National Sample of College Students. J Adolesc Health 57:144-9
Munn-Chernoff, Melissa A; Grant, Julia D; Bucholz, Kathleen K et al. (2015) Bulimic Behaviors and Early Substance Use: Findings from a Cotwin-Control Study. Alcohol Clin Exp Res 39:1740-8
Munn-Chernoff, Melissa A; Keel, Pamela K; Klump, Kelly L et al. (2015) Prevalence of and familial influences on purging disorder in a community sample of female twins. Int J Eat Disord 48:601-6
Munn-Chernoff, Melissa A; Grant, Julia D; Agrawal, Arpana et al. (2015) Are there common familial influences for major depressive disorder and an overeating-binge eating dimension in both European American and African American female twins? Int J Eat Disord 48:375-82
Genetics of Personality Consortium; de Moor, Marleen H M; van den Berg, Stéphanie M et al. (2015) Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. JAMA Psychiatry 72:642-50
Duncan, Alexis E; Sartor, Carolyn E; Jonson-Reid, Melissa et al. (2015) Associations between body mass index, post-traumatic stress disorder, and child maltreatment in young women. Child Abuse Negl 45:154-62
Blustein, Erica C; Munn-Chernoff, Melissa A; Grant, Julia D et al. (2015) The Association of Low Parental Monitoring With Early Substance Use in European American and African American Adolescent Girls. J Stud Alcohol Drugs 76:852-61
Munn-Chernoff, Melissa A; Grant, Julia D; Agrawal, Arpana et al. (2015) Genetic overlap between alcohol use disorder and bulimic behaviors in European American and African American women. Drug Alcohol Depend 153:335-40

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