The proposed program, "Research Training in Biogerontology," seeks a five-year continuation (-26 to -30) of our current award, a grant originally funded in 1985 and supported through April of 2010. Funds to support 6 predoctoral and 3 postdoctoral trainees are requested, matching current program size. This Program is situated within a Geriatrics Center that provides an exceptionally rich intellectual environment for research and training in the biology of aging, through its dedicated research space, Pepper Center, Nathan Shock Center, and GRECC core grants, multiple NIA-funded R01, U01, and P01 grants, and recent recruitment of new faculty. The Preceptor group includes 23 well-funded faculty members from 15 departments. The main goal of the Training Program is to select, train and prepare graduate students and postdoctoral fellows for careers as leaders in biological and biomedical aging research. Predoctoral trainees are accepted into the program only after they have completed departmental course requirements and embarked on full-time research programs. The main activity of each predoctoral and postdoctoral trainee is the development of a faculty-supervised research project leading to discoveries and peer-reviewed publications on important questions in the biology of aging. Trainee research projects are also expected to meet the highest professional standards in cognate disciplines of neuroscience, genetics, cell biology, biochemistry, immunology and physiology. In addition to discipline-specific training provided by the mentor and department, each trainee also benefits from Training Program activities that provide deep and broad background in modern aging research. These include a biweekly research series in which faculty presentations alternate with trainee research-in-progress talks;a monthly journal club;participation in Shock and Pepper Center annual research retreats;presentations at the annual Geriatrics Center research symposium;and opportunities to interact with guest speakers who visit each year to discuss topics in aging and geriatrics. Trainees also benefit from the University's well-established resources for training in the responsible conduct of research. The physical resources available to trainees through the Geriatrics Center and the University are outstanding, and include over 17,000 sq. ft. of wet lab space in the newly opened Biomedical Sciences Research Building, as well as the Medical Center's many sophisticated technical core facilities.

Public Health Relevance

High quality training in the biology of aging will prepare students and trainees for outstanding careers at the forefront of Biogerontology, helping them make discoveries in the relation of aging to the diseases that afflict people in the second half of their lifespan.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AG000114-29
Application #
8458517
Study Section
Special Emphasis Panel (ZAG1-ZIJ-3 (J3))
Program Officer
Velazquez, Jose M
Project Start
1985-09-01
Project End
2015-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
29
Fiscal Year
2013
Total Cost
$409,790
Indirect Cost
$27,068
Name
University of Michigan Ann Arbor
Department
Physiology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Dostál, Lubomír; Kohler, William M; Penner-Hahn, James E et al. (2015) Fibroblasts from long-lived rodent species exclude cadmium. J Gerontol A Biol Sci Med Sci 70:9-Oct
Kung, Theodore A; Cederna, Paul S; van der Meulen, Jack H et al. (2014) Motor unit changes seen with skeletal muscle sarcopenia in oldest old rats. J Gerontol A Biol Sci Med Sci 69:657-65
Waterson, Michael J; Chung, Brian Y; Harvanek, Zachary M et al. (2014) Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling. Proc Natl Acad Sci U S A 111:8137-42
Ro, Jennifer; Harvanek, Zachary M; Pletcher, Scott D (2014) FLIC: high-throughput, continuous analysis of feeding behaviors in Drosophila. PLoS One 9:e101107
Buschkuehl, Martin; Hernandez-Garcia, Luis; Jaeggi, Susanne M et al. (2014) Neural effects of short-term training on working memory. Cogn Affect Behav Neurosci 14:147-60
Ostojic, Ivan; Boll, Werner; Waterson, Michael J et al. (2014) Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signaling. Proc Natl Acad Sci U S A 111:8143-8
Gendron, Christi M; Kuo, Tsung-Han; Harvanek, Zachary M et al. (2014) Drosophila life span and physiology are modulated by sexual perception and reward. Science 343:544-8
Atkin, Graham; Hunt, Jack; Minakawa, Eiko et al. (2014) F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing. J Biol Chem 289:7038-48
Zhang, H; Yu, C; Dai, J et al. (2014) Parathyroid hormone-related protein inhibits DKK1 expression through c-Jun-mediated inhibition of *-catenin activation of the DKK1 promoter in prostate cancer. Oncogene 33:2464-77
Giblin, William; Skinner, Mary E; Lombard, David B (2014) Sirtuins: guardians of mammalian healthspan. Trends Genet 30:271-86

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