This application requests continued support for a Training Program initiated at the University of Wisconsin- Madison (UW) in 1991. The application builds upon the remarkable resources of the UW in aging research, and includes 25 widely acknowledged faculty mentors from several departments, schools and institutes from across the UW campus. They are committed to providing each predoctoral (n=4, at least one position to support MD/PhD student) and postdoctoral trainee (n=4) with an outstanding training experience. The major objective of the program is to select talented and focused trainees who, following completion of their NIA- supported training, will pursue successful academic careers in either the basic biology or translational research in aging. Funded by the NIA for over 15 years, the present Training Program continues to excel in its missions and evolve in a favorable direction. In May 2005, Dr. Asthana took over the leadership of the program and, consistent with the NIH Roadmap Initiative, enhanced access of trainees to translational and clinical research, while maintaining its major focus on the biology of aging research. Additionally, in response to comments included in the last competing review of the program, Dr. Asthana instituted additional programmatic changes, including revision of the mentors list, enhanced efforts to recruit minority trainees, improvement of a formal trainee selection process, vigorous enforcement of policies related to attendance in seminars and other educational activities, institution of a formal process to evaluate the mentors, trainees and the program as a whole, and creation of an Advisory Committee. Additionally, all trainees continue to be mandated to complete a course on Responsible Conduct of Research. Overall, the present competing renewal application of a highly successful T 32 Training Program proposes to build upon its strengths and academic excellence of UW in aging research, and provide world class interdisciplinary training to both predoctoral and postdoctoral fellows, helping them excel in their academic careers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
3T32AG000213-21S1
Application #
8444796
Study Section
Special Emphasis Panel (ZAG1-ZIJ-9 (J2))
Program Officer
Velazquez, Jose M
Project Start
1991-07-01
Project End
2013-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
21
Fiscal Year
2012
Total Cost
$55,582
Indirect Cost
$6,604
Name
University of Wisconsin Madison
Department
Other Health Professions
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Darst, Burcu F; Koscik, Rebecca L; Racine, Annie M et al. (2017) Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-? Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease. J Alzheimers Dis 55:473-484
Cummings, Nicole E; Williams, Elizabeth M; Kasza, Ildiko et al. (2017) Restoration of metabolic health by decreased consumption of branched-chain amino acids. J Physiol :
Nicholas, Christopher R; Hoscheidt, Siobhan M; Clark, Lindsay R et al. (2017) Positive affect predicts cerebral glucose metabolism in late middle-aged adults. Soc Cogn Affect Neurosci 12:993-1000
Geddes, Rastafa I; Hayashi, Kentaro; Bongers, Quinn et al. (2017) Conjugated Linoleic Acid Administration Induces Amnesia in Male Sprague Dawley Rats and Exacerbates Recovery from Functional Deficits Induced by a Controlled Cortical Impact Injury. PLoS One 12:e0169494
Miller, Karl N; Burhans, Maggie S; Clark, Josef P et al. (2017) Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipids. Aging Cell 16:497-507
Racine, Annie M; Merluzzi, Andrew P; Adluru, Nagesh et al. (2017) Association of longitudinal white matter degeneration and cerebrospinal fluid biomarkers of neurodegeneration, inflammation and Alzheimer's disease in late-middle-aged adults. Brain Imaging Behav :
Schneider, Augusto; Dhahbi, Joseph M; Atamna, Hani et al. (2017) Caloric restriction impacts plasma microRNAs in rhesus monkeys. Aging Cell 16:1200-1203
Neuman, Joshua C; Schaid, Michael D; Brill, Allison L et al. (2017) Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E2 Signaling and Enhances Diabetic ?-Cell Function. Diabetes 66:1572-1585
Burkel, Brian; Morris, Brett A; Ponik, Suzanne M et al. (2016) Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo. J Vis Exp :
Martin, Stephen A; DeMuth, Tyler M; Miller, Karl N et al. (2016) Regional metabolic heterogeneity of the hippocampus is nonuniformly impacted by age and caloric restriction. Aging Cell 15:100-10

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