Funded by NIA in 1991, this revised T32 requests continued support for 4 predoctoral and 4 postdoctoral fellows in aging research at the University of Wisconsin-Madison. The major mission of this program is to provide interdisciplinary, state-of-the-art training to talented pre- and post-doctoral fellows in both the biology and clinical/translational research in aging and related diseases. Similar to prior trainees, it is projected that the majority of trainees in the next funding period will pursue successful academic careers, and provides leadership to eminent programs in aging research across the country. The revised application builds upon the remarkable resources of UW in gerontology, and includes 34 (14 women and 20 men) faculty mentors with acknowledged expertise in aging research. Each mentor has a noted history of conducting research in aging and training successful scientists in gerontology research. Based on outstanding input from reviewers of the original application, the present proposal includes junior faculty who will be co-mentored by senior faculty to become successful mentors. For over 20 years, this T32 has received substantial institutional commitment. The present application includes additional financial commitments, including support for a new (i.e., 5th position) predoctoral position each year and funds to cover 5% effort for both the Program Director and Co-Director. Additional strengths of this application include: 1) access to training in new areas of aging research not previously included in this T32, 2) inclusion of 13 new faculty mentors of which 11 are women, 3) balanced distribution of mentors between junior, mid-level and senior faculty ranks, 4) confirmation that this training program does not overlap with any other T32 at UW, 5) enhanced efforts to increase recruitment and retention of trainees of color, and 6) inclusion of a strong training curriculum in both basic biological and clinical research. Overall, the present revised T32 has undergone major revisions and is significantly strengthened. It will continue to provide outstanding training to talented young scientists in both laboratory-based and clinical/translational research in aging and related diseases, and help them launch a successful academic career in gerontology.
The major mission of this T32 is to train highly talented, well-qualified pre- and post- doctoral fellows in aging research. Given the projected increase in the number of older adults living in the US by 2050, it is critical that significant advances be made toward understanding the biology of aging and related diseases, and to improve management of chronic diseases commonly seen in the elderly. The present T32 Program will provide state-of-the-art training in aging research to young talented scientists, expected to pursue academic careers at institutions throughout the country. These scientists will make novel contributions toward understanding the biology and enhancing management of disabling diseases of aging.
|Morris, Brett A; Burkel, Brian; Ponik, Suzanne M et al. (2016) Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells. EBioMedicine 13:146-156|
|Racine, Annie M; Clark, Lindsay R; Berman, Sara E et al. (2016) Associations between Performance onÂ anÂ Abbreviated CogState Battery, OtherÂ Measures of Cognitive Function, andÂ Biomarkers in People at Risk forÂ Alzheimer's Disease. J Alzheimers Dis 54:1395-1408|
|Morris, Zachary S; Saha, Sandeep; Magnuson, William J et al. (2016) Increased tumor response to neoadjuvant therapy among rectal cancer patients taking angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. Cancer 122:2487-95|
|Busch, Rebecca A; Heneghan, Aaron F; Pierre, Joseph F et al. (2016) Bombesin Preserves Goblet Cell Resistin-Like Molecule Î² During Parenteral Nutrition but Not Other Goblet Cell Products. JPEN J Parenter Enteral Nutr 40:1042-9|
|Burkel, Brian; Morris, Brett A; Ponik, Suzanne M et al. (2016) Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo. J Vis Exp :|
|Wisinski, Jaclyn A; Kimple, Michelle E (2016) Platelet Dysfunction in Type 1 Diabetes: Stressing the Thromboxanes. Diabetes 65:349-51|
|Martin, Stephen A; DeMuth, Tyler M; Miller, Karl N et al. (2016) Regional metabolic heterogeneity of the hippocampus is nonuniformly impacted by age and caloric restriction. Aging Cell 15:100-10|
|Baan, Mieke; Krentz, Kathleen J; Fontaine, Danielle A et al. (2016) Successful in vitro fertilization and generation of transgenics in Black and Tan Brachyury (BTBR) mice. Transgenic Res 25:847-854|
|Heninger, Erika; Krueger, Timothy E G; Thiede, Stephanie M et al. (2016) Inducible expression of cancer-testis antigens in human prostate cancer. Oncotarget :|
|Fontaine, Danielle A; Davis, Dawn Belt (2016) Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium. Diabetes 65:25-33|
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