This application represents the third competitive renewal for our Training Program that prepares young investigators to conduct research in age-related neurodegenerative diseases. Through an intensive program of education, research training, and mentorship, these trainees will become independent investigators who will pursue careers to further our understanding of the etiology, pathogenesis, diagnosis, and treatment of these diseases. Trainees will include predoctoral PhD and MD/PhD students in neuroscience and related disciplines as well as postdoctoral PhD and MD scientists with prior training in the neurosciences, pharmacology, neuropathology, psychiatry, and gerontology. Predoctoral trainees will be given a solid background in neuroscience and related disciplines, including exposure to many diverse techniques, methods, and approaches in the setting of a research intensive academic medical center and university with a highly interactive group of trainers. They will then select a mentor from a pool of seventeen trainers with wide-ranging interests and complementary expertise. Postdoctoral trainees will participate actively in investigations underway in the laboratory of their choosing. Joint supervision of a trainee by more than one trainer will be encouraged;and physician trainees will also have the opportunity to pursue patient oriented research. Penn has an extensive didactive program in neurosciences, pharmacology, and other basic sciences that can be individually tailored to the needs of each trainee as a supplement to their core research training. Each trainee will undertake an independent project that will provide experience in the design and analysis of experiments and in the presentation and publication of results. Trainees will also participate in weekly research seminars that promote a constant interchange among trainees and trainers and encourage collaboration.

Public Health Relevance

This program includes education and research opportunities for predoctoral and postdoctoral trainees to prepare them for research careers in age-related human neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral Sclerosis (ALS), frontotemporal degeneration (FTD), and frontemporal lobar degeneration (FTLD). These diseases are a significant and expanding public health problem due to the rapidly aging global population.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZAG1-ZIJ-3 (J1))
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Petanceska, Suzana
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University of Pennsylvania
Schools of Medicine
United States
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Tuttle, Marcus D; Comellas, Gemma; Nieuwkoop, Andrew J et al. (2016) Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein. Nat Struct Mol Biol 23:409-15
Luk, Kelvin C; Covell, Dustin J; Kehm, Victoria M et al. (2016) Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity. Cell Rep 16:3373-87
Haney, Conor M; Wissner, Rebecca F; Warner, John B et al. (2016) Comparison of strategies for non-perturbing labeling of α-synuclein to study amyloidogenesis. Org Biomol Chem 14:1584-92
Ho, Tina; Watt, Brenda; Spruce, Lynn A et al. (2016) The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation. J Biol Chem 291:3595-612
Kang, Ju-Hee; Mollenhauer, Brit; Coffey, Christopher S et al. (2016) CSF biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study. Acta Neuropathol 131:935-49
Price, Amy Rose; Peelle, Jonathan E; Bonner, Michael F et al. (2016) Causal Evidence for a Mechanism of Semantic Integration in the Angular Gyrus as Revealed by High-Definition Transcranial Direct Current Stimulation. J Neurosci 36:3829-38
Klinman, Eva; Holzbaur, Erika L F (2016) Comparative analysis of axonal transport markers in primary mammalian neurons. Methods Cell Biol 131:409-24
Burguete, Alondra Schweizer; Almeida, Sandra; Gao, Fen-Biao et al. (2015) GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function. Elife 4:e08881
Price, Amy R; McAdams, Harrison; Grossman, Murray et al. (2015) A Meta-analysis of Transcranial Direct Current Stimulation Studies Examining the Reliability of Effects on Language Measures. Brain Stimul 8:1093-100
Klinman, Eva; Holzbaur, Erika L F (2015) Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein. Cell Rep 12:462-73

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