The University of Maryland College Park Department of Kinesiology exercise biology and aging program has a history of producing well-trained PhDs who complete postdoctoral training and become productive faculty members. We have supported 18 trainees over the first 9 yrs of this program with 12 completing their PhD degrees, 5 still in training, and 1 pursuing an MD/PhD degree in a different discipline (neuroscience). Eleven of the 12 who graduated (92%) have gone on to NIH postdoctoral research fellowships. Seven of these 12 graduates are now in tenure-track academic positions, 1 is in industry, 1 is part-time faculty, and 3 are still in postdoctoral positions. Furthermore, we have graduated 3 African-American women who have gone on to NIH postdoctoral research fellowships at UT-Southwestern, Wake Forest, and Temple. This program provides trainees with the skills necessary for them to complete high-quality dissertation research projects addressing: 1) age-related changes in body composition, metabolic, CV, and musculoskeletal function, and CV disease risk factors;2) exercise training-induced changes in these same parameters;3) the genetic architecture underlying the baseline measures of these parameters, their changes with aging, and their changes with exercise training interventions;and 4) the mechanisms responsible for these responses in animal and cell culture models using cell and molecular biology methodologies. A substantial enhancement of this renewal Training Program is this translational component, whereby trainees can extend their studies from human physiological studies to investigations in animal models and cell culture to delineate the underlying cell and molecular mechanisms. Trainees'research can be conducted with Primary, Secondary, and Associate Mentors at closely collaborating laboratories at the University of Maryland School of Medicine Division of Gerontology, Division of Endocrinology, Diabetes, and Nutrition, Department of Physiology, and School of Nursing and Childrens National Medical Center Research Center for Genetic Medicine. Trainees complete coursework in the basic biology of aging;specific knowledge in exercise, CV, musculoskeletal, metabolic, cell, and molecular biology and physiology;genetics;and biostatistics and research design. We propose to continue this program to fund each of 6 predoctoral trainees for 4 yrs to complete their PhD degrees with high-quality coursework and a dissertation research project that will prepare them for an NIH postdoctoral research fellowship and an eventual academic faculty position with a research program focusing on exercise biology and aging.

Public Health Relevance

(Seeinstructions): This program will support 6 trainees/yr to complete their PhD degrees with a high-quality dissertation research project. The long-term goal is to prepare trainees to pursue high-level NIH postdoctoralresearch fellowships and, eventually, academic faculty positions that focus on research and teaching in the prevention of such major age-associated issues as sarcopenia, obesity, diabetes, hypertension, and CV disease.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AG000268-14
Application #
8243509
Study Section
Special Emphasis Panel (ZAG1-ZIJ-7 (J4))
Program Officer
Dutta, Chhanda
Project Start
1999-05-01
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
14
Fiscal Year
2012
Total Cost
$213,723
Indirect Cost
$12,951
Name
University of Maryland College Park
Department
Miscellaneous
Type
Schools of Public Health
DUNS #
790934285
City
College Park
State
MD
Country
United States
Zip Code
20742
Ludlow, Andrew T; Spangenburg, Espen E; Chin, Eva R et al. (2014) Telomeres shorten in response to oxidative stress in mouse skeletal muscle fibers. J Gerontol A Biol Sci Med Sci 69:821-30
Landers-Ramos, Rian Q; Jenkins, Nathan T; Spangenburg, Espen E et al. (2014) Circulating angiogenic and inflammatory cytokine responses to acute aerobic exercise in trained and sedentary young men. Eur J Appl Physiol 114:1377-84
Brandauer, Josef; Landers-Ramos, Rian Q; Jenkins, Nathan T et al. (2013) Effects of prior acute exercise on circulating cytokine concentration responses to a high-fat meal. Physiol Rep 1:e00040
Guth, Lisa M; Ludlow, Andrew T; Witkowski, Sarah et al. (2013) Sex-specific effects of exercise ancestry on metabolic, morphological and gene expression phenotypes in multiple generations of mouse offspring. Exp Physiol 98:1469-84
Guth, Lisa M; Roth, Stephen M (2013) Genetic influence on athletic performance. Curr Opin Pediatr 25:653-8
Prior, Steven J; Jenkins, Nathan T; Brandauer, Josef et al. (2012) Aerobic exercise training increases circulating insulin-like growth factor binding protein-1 concentration, but does not attenuate the reduction in circulating insulin-like growth factor binding protein-1 after a high-fat meal. Metabolism 61:310-6
Bjork, L; Jenkins, N T; Witkowski, S et al. (2012) Nitro-oxidative stress biomarkers in active and inactive men. Int J Sports Med 33:279-84
Jenkins, Nathan T; Landers, Rian Q; Thakkar, Sunny R et al. (2011) Prior endurance exercise prevents postprandial lipaemia-induced increases in reactive oxygen species in circulating CD31+ cells. J Physiol 589:5539-53
Jenkins, Nathan T; Landers, Rian Q; Prior, Steven J et al. (2011) Effects of acute and chronic endurance exercise on intracellular nitric oxide and superoxide in circulating CD34ýýý and CD34ýýý cells. J Appl Physiol 111:929-37
Jenkins, Nathan T; McKenzie, Jennifer A; Hagberg, James M et al. (2011) Plasma fetuin-A concentrations in young and older high- and low-active men. Metabolism 60:265-71

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