This proposal requests funds for a predoctoral training program in disease oriented basic neuroscience with an emphasis on aging and age-related neurological disorders. We are requesting support for five pre-doctoral trainees. The program is designed to offer PhD students rigorous and specialized training in the neurobiology of aging and age-related neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease. Huntington's disease and stroke. The Graduate Program in Neuroscience at Rush University Medical Center is one of the few programs that offers training in disease oriented basic neuroscience;it is housed in the Deptament of Neurological Sciences, a department where a large number of basic scientists and clinicians work very closely together. Preceptors for the proposed predoctoral training program include nine basic scientists with well funded research programs and a long-standing commitment to aging research;their expertise ranges all the way from molecular and structural biology to electrophysiology, imaging and behavior. Additional teaching faculty include other basic scientists and clinicians in the Department of Neurological Sciences, as well as members of other divisions within the Graduate College of Rush University Medical Center.
This training program is one of the few in the country offering pre-doctoral training in disease oriented basic neuroscience. By being exposed to basic scientists and clinicians who work very closely together in the same department, our trainees receive knowledge important for the understanding of age-related neurodegenerative diseases. Scientists with this kind of training will be able to carry out research that in the future could lead to prevention or even cure of these diseases.
|Corbett, Grant T; Gonzalez, Frank J; Pahan, Kalipada (2015) Activation of peroxisome proliferator-activated receptor ? stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A 112:8445-50|
|Goldman, Jennifer G; Aggarwal, Neelum T; Schroeder, Cynthia D (2015) Mild cognitive impairment: an update in Parkinson's disease and lessons learned from Alzheimer's disease. Neurodegener Dis Manag 5:425-43|
|Kelley, Christy M; Powers, Brian E; Velazquez, Ramon et al. (2014) Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice. J Comp Neurol 522:1390-410|
|Kelley, Christy M; Powers, Brian E; Velazquez, Ramon et al. (2014) Sex differences in the cholinergic basal forebrain in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease. Brain Pathol 24:33-44|
|Corbett, Grant T; Buss, Eric W (2014) Non-neuronal cells exacerbate ?-amyloid aggregation in the aged brain. J Neurosci 34:9825-7|
|Velazquez, Ramon; Ash, Jessica A; Powers, Brian E et al. (2013) Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 58:92-101|
|Li, Xin; Kroin, Jeffrey S; Kc, Ranjan et al. (2013) Altered spinal microRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints. J Bone Miner Res 28:2512-22|
|Menon, Vilas; Musial, Timothy F; Liu, Annie et al. (2013) Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites. Neuron 80:1451-63|
|Dougherty, Kelly A; Nicholson, Daniel A; Diaz, Laurea et al. (2013) Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus. J Neurophysiol 109:1940-53|
|Corbett, Grant T; Roy, Avik; Pahan, Kalipada (2013) Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy. J Biol Chem 288:8299-312|
Showing the most recent 10 out of 23 publications