The proposed program represents a 5-year continuation of an institutional training grant in the biology of aging, which was encompasses diverse investigators from 7 academic departments at UT Health Science Center San Antonio (UTHSCSA). We request funds to support 10 predoctoral and 6 postdoctoral trainees. The impending avalanche of elderly in the US combined with major recent advances in understanding fundamental mechanisms of aging has created a substantial demand for researchers trained to investigate means of delaying and relieving the ailments of an aging population. UTHSCSA is a premier research institution in the biology of aging, with the largest faculty in the country whose research is devoted primarily to the basic biology of aging. The primary goal of the proposed Training Program is to intellectually prepare both graduate students and postdoctoral fellows for careers as leaders in basic biological research in aging. The Training Program involves 26 faculty members (16 men, 10 women) and takes advantage of the synergies created by intensely collaborative personnel, the unique resources available from our Nathan Shock Center of Excellence in the Biology of Aging and the institutional commitment to, and expanding resources of, the Barshop Institute itself. Trainees will be chosen competitively based on academic excellence, their interest in aging research, and motivation for careers in research. The main activity of each trainee is the development of their faculty- supervised research project, which because of the extensive collaboration among our faculty tends to result surprisingly often in co-mentorships. Trainees have thrived with dual mentorships to the point that we have now institutionalized it as an obligatory feature of our training program Another key component is to require broad knowledge in the biology of aging acquired in our biology of aging course such that trainees'can place their research in an appropriate scientific context. In addition to this formal didactic training, we require trainees to attend the weekly Aging Research Journal Club and present at, as well as attend, our weekly Barshop Institute seminar series and annual trainee retreat. Training in grant writing skills resulting in an F- seris grant proposal for individual NRSAs are accomplished by all trainees within the first 18 months of entering our training program.

Public Health Relevance

The tsunami of aging baby-boomers that is about to wash over our healthcare system makes it imperative that we find ways to improve and preserve human health. Basic aging researchers are making many strides towards this goal. Training additional researchers in this field is both scientifically and medically critical.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-3 (J1))
Program Officer
Velazquez, Jose M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Health Science Center San Antonio
Schools of Medicine
San Antonio
United States
Zip Code
Lewis, Kaitlyn N; Rubinstein, Nimrod D; Buffenstein, Rochelle (2018) A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence. Geroscience 40:105-121
Garbarino, Valentina R; Gilman, T Lee; Daws, Lynette C et al. (2018) Extreme enhancement or depletion of serotonin transporter function and serotonin availability in autism spectrum disorder. Pharmacol Res :
Jahrling, Jordan B; Lin, Ai-Ling; DeRosa, Nicholas et al. (2018) mTOR drives cerebral blood flow and memory deficits in LDLR-/- mice modeling atherosclerosis and vascular cognitive impairment. J Cereb Blood Flow Metab 38:58-74
Van Skike, Candice E; Jahrling, Jordan B; Olson, Angela B et al. (2018) Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol 314:H693-H703
Zhang, Shen-Ying; Clark, Nathaniel E; Freije, Catherine A et al. (2018) Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection. Cell 172:952-965.e18
Van Skike, Candice E; Galvan, Veronica (2018) A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review. Gerontology 64:205-211
Deng, Yilun; Qin, Yuejuan; Srikantan, Subramanya et al. (2018) The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex. Hum Mol Genet 27:1794-1808
Kraig, Ellen; Linehan, Leslie A; Liang, Hanyu et al. (2018) A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects. Exp Gerontol 105:53-69
Deepa, Sathyaseelan S; Pharaoh, Gavin; Kinter, Michael et al. (2018) Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice. Aging Cell :e12769
Zhang, Ning; Valentine, Joseph M; Zhou, You et al. (2017) Sustained NF?B inhibition improves insulin sensitivity but is detrimental to muscle health. Aging Cell 16:847-858

Showing the most recent 10 out of 124 publications