The proposed program represents a 5-year continuation of an institutional training grant in the biology of aging, which was encompasses diverse investigators from 7 academic departments at UT Health Science Center San Antonio (UTHSCSA). We request funds to support 10 predoctoral and 6 postdoctoral trainees. The impending avalanche of elderly in the US combined with major recent advances in understanding fundamental mechanisms of aging has created a substantial demand for researchers trained to investigate means of delaying and relieving the ailments of an aging population. UTHSCSA is a premier research institution in the biology of aging, with the largest faculty in the country whose research is devoted primarily to the basic biology of aging. The primary goal of the proposed Training Program is to intellectually prepare both graduate students and postdoctoral fellows for careers as leaders in basic biological research in aging. The Training Program involves 26 faculty members (16 men, 10 women) and takes advantage of the synergies created by intensely collaborative personnel, the unique resources available from our Nathan Shock Center of Excellence in the Biology of Aging and the institutional commitment to, and expanding resources of, the Barshop Institute itself. Trainees will be chosen competitively based on academic excellence, their interest in aging research, and motivation for careers in research. The main activity of each trainee is the development of their faculty- supervised research project, which because of the extensive collaboration among our faculty tends to result surprisingly often in co-mentorships. Trainees have thrived with dual mentorships to the point that we have now institutionalized it as an obligatory feature of our training program Another key component is to require broad knowledge in the biology of aging acquired in our biology of aging course such that trainees' can place their research in an appropriate scientific context. In addition to this formal didactic training, we require trainees to attend the weekly Aging Research Journal Club and present at, as well as attend, our weekly Barshop Institute seminar series and annual trainee retreat. Training in grant writing skills resulting in an F- seris grant proposal for individual NRSAs are accomplished by all trainees within the first 18 months of entering our training program.

Public Health Relevance

The tsunami of aging baby-boomers that is about to wash over our healthcare system makes it imperative that we find ways to improve and preserve human health. Basic aging researchers are making many strides towards this goal. Training additional researchers in this field is both scientifically and medically critical.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Velazquez, Jose M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Health Science Center
Internal Medicine/Medicine
Schools of Medicine
San Antonio
United States
Zip Code
Katolik, Adam; Clark, Nathaniel E; Tago, Nobuhiro et al. (2017) Fluorescent Branched RNAs for High-Throughput Analysis of Dbr1 Enzyme Kinetics and Inhibition. ACS Chem Biol 12:622-627
Apple, Deana M; Fonseca, Rene Solano; Kokovay, Erzsebet (2017) The role of adult neurogenesis in psychiatric and cognitive disorders. Brain Res 1655:270-276
Lin, Ai-Ling; Jahrling, Jordan B; Zhang, Wei et al. (2017) Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease. J Cereb Blood Flow Metab 37:217-226
Mishra, Anuja; Qiu, Zhifang; Farnsworth, Steven L et al. (2016) Induced Pluripotent Stem Cells from Nonhuman Primates. Methods Mol Biol 1357:183-93
Clark, Nathaniel E; Katolik, Adam; Roberts, Kenneth M et al. (2016) Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1. Proc Natl Acad Sci U S A 113:14727-14732
Triplett, Judy C; Swomley, Aaron M; Cai, Jian et al. (2016) Quantitative phosphoproteomic analyses of the inferior parietal lobule from three different pathological stages of Alzheimer's disease. J Alzheimers Dis 49:45-62
Lopez-Cruzan, M; Sharma, R; Tiwari, M et al. (2016) Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment. Cell Death Discov 2:
Munk√°csy, Erin; Khan, Maruf H; Lane, Rebecca K et al. (2016) DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. PLoS Genet 12:e1006133
Hambright, W S; Deng, Jie; Tiedje, James M et al. (2016) Shewanella baltica Ecotypes Have Wide Transcriptional Variation under the Same Growth Conditions. mSphere 1:
Panchal, Shweta; Chitrakar, Reejana; Thompson, Blaine K et al. (2016) Regulation of Stomatal Defense by Air Relative Humidity. Plant Physiol 172:2021-2032

Showing the most recent 10 out of 113 publications