This T32-supported ?Training Program in Gerontological and Geriatric Research (TPGGR)?, initially funded in 2009 (for 2 years), and subsequently renewed for 5 years in 2012, has supported mentored training of 5 successful investigators who remain dedicated to a research career, with 2 new fellows committed to begin training in summer/fall 2016. Our 6-year progress is on track to exceed program goals, consistent with our faculty's overall track record of outstanding success in educating other students, postdoctoral fellows, and early-career faculty. Nationwide, there is a dearth of competent investigators trained in the appropriate research skills who wish to conduct clinical research on important geriatric outcomes that lead to mobility disability, dementia, and loss of independence. Thus, the research of our T32-supported trainees has been, and will continue to be, instrumental in advancing knowledge regarding the prevention of disability and the best health care for older adults. The overall goal of our TPGGR is to provide an integrated career development pathway centered on training fellows in the skills and competencies needed to conduct clinical research directed at prevention of physical and cognitive disability. Our scholars acquire a scientific understanding of the pathways leading to physical and/or cognitive disability, as well as gain: 1) competencies needed to conduct randomized clinical trials and/or longitudinal cohort studies in the elderly, 2) experience and expertise in the measurement of cognitive and/or physical disability outcomes, and 3) specific technical or methodological skills in line with their individual interests. This training will place them in a position to transition successfully to an early-stage faculty position and to be highly competitive for new funding to continue their path towards independence. This approach complements our other training programs and integrates perfectly with the scientific themes of our existing NIA-sponsored Pepper Center, which is focused on physical function, and our endowed Kulynych Center, which is focused on cognitive function. Since our initial T32 grant, the number of research-intensive faculty and extramural funding in our Sticht Center has nearly doubled. Because of this explosion in our number of highly qualified training faculty, this proposal seeks annual salary support for 3 trainees. With a current research portfolio of funded grants totaling $28.4 million in direct costs awarded to our proposed T32 Program Faculty, we have the scientific expertise, resources, and research opportunities available for training the next generation of investigators for success in clinical geriatric research.

Public Health Relevance

Expanding knowledge of the best ways to prevent and treat aging-related chronic disease and disability requires the conduct of quality research performed by competent and experienced research scientists. This training program will provide resources for post-doctoral trainees to develop a research career through practical experience with an experienced mentor and through additional formal education. Scholars will emerge from the program with a scientific understanding of the pathways leading to aging-related disability, and with a specific set of technical research skills. This will enhance the overall development of future research leaders in geriatric research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
2T32AG033534-08
Application #
9278711
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Eldadah, Basil A
Project Start
2009-05-01
Project End
2022-04-30
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
8
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Justice, Jamie N; Silverstein-Metzler, Marnie G; Uberseder, Beth et al. (2017) Relationships of depressive behavior and sertraline treatment with walking speed and activity in older female nonhuman primates. Geroscience 39:585-600
Cavalli, Giulio; Justice, Jamie N; Boyle, Kristen E et al. (2017) Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance. Proc Natl Acad Sci U S A 114:2313-2318
Taylor, Jackson; Reynolds, Lindsay; Hou, Li et al. (2017) Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice. Immun Ageing 14:15
Silverstein-Metzler, Marnie G; Justice, Jamie N; Appt, Susan E et al. (2017) Long-term sertraline treatment and depression effects on carotid artery atherosclerosis in premenopausal female primates. Menopause 24:1175-1184
Stout, Michael B; Justice, Jamie N; Nicklas, Barbara J et al. (2017) Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty. Physiology (Bethesda) 32:9-19
Hughes, Timothy M; Craft, Suzanne; Lopez, Oscar L (2015) Review of 'the potential role of arterial stiffness in the pathogenesis of Alzheimer's disease'. Neurodegener Dis Manag 5:121-35
Reynolds, Lindsay M; Ding, Jingzhong; Taylor, Jackson R et al. (2015) Transcriptomic profiles of aging in purified human immune cells. BMC Genomics 16:333
Taylor, Jackson; Pereyra, Andrea; Zhang, Tan et al. (2014) The Cav?1a subunit regulates gene expression and suppresses myogenin in muscle progenitor cells. J Cell Biol 205:829-46
Reynolds, Lindsay M; Taylor, Jackson R; Ding, Jingzhong et al. (2014) Age-related variations in the methylome associated with gene expression in human monocytes and T cells. Nat Commun 5:5366
Hughes, Timothy M; Lopez, Oscar L; Evans, Rhobert W et al. (2014) Markers of cholesterol transport are associated with amyloid deposition in the brain. Neurobiol Aging 35:802-7

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